Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 18/20 | 0.74 |
| ▸ | MTNR1B | P49286 | 18/20 | 0.74 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | NQO2 | P16083 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7054087 | 0.69 | MTNR1A (0.57) | MTNR1AMTNR1B | |
| SCHEMBL18800036 | 0.69 | MTNR1A (0.74) | MTNR1AMTNR1BNQO2 | |
| SCHEMBL7055579 | 0.69 | MTNR1A (0.48) | MTNR1AMTNR1B | |
| SCHEMBL7053303 | 0.67 | MTNR1A (0.51) | MTNR1AMTNR1BAKR1C3 | |
| SCHEMBL9046975 | 0.67 | AKR1C3 (0.44) | MTNR1AMTNR1BAKR1C3 | |
| SCHEMBL7057717 | 0.67 | MTNR1A (0.53) | MTNR1AMTNR1B | |
| SCHEMBL6944686 | 0.65 | MTNR1A (0.57) | MTNR1AMTNR1BNQO2 | |
| SCHEMBL456877 | 0.65 | MTNR1A (0.42) | MTNR1AMTNR1BAKR1C3 | |
| SCHEMBL10566139 | 0.65 | MTNR1A (0.56) | MTNR1AMTNR1BAKR1C3NQO2 | |
| SCHEMBL7050429 | 0.65 | MTNR1A (0.53) | MTNR1AMTNR1BAKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0656209-B1 | Melatonin derivatives for use in treating desynchronization disorders | LILLY CO ELI (US) | 2003-05-07 | — | — | EP | disclosed |
| EP-0655243-B1 | Melatonin derivatives for use in treating sleep disorders | LILLY CO ELI (US) | 2002-08-21 | — | — | EP | disclosed |
| US-6180657-B1 | SLEEP DISORDERS | ELI LILLY AND COMPANY | 2001-01-30 | — | — | US | disclosed |
| US-5770610-A | ADMINISTERING R-(+)-N-(2-METHYL-2-(5-METHOXY-6-CHLOROINDOL-3-YL)ETHYL) ACETAMIDE | ELI LILLY AND COMPANY (US) | 1998-06-23 | — | — | US | disclosed |
| US-5654325-A | Melatonin derivatives for use in treating sleep disorders | ELI LILLY AND COMPANY (US) | 1997-08-05 | — | — | US | disclosed |
| EP-0748627-A2 | Melatonin agonists for use in the treatment of benign prostatic hyperplasia | ELI LILLY AND COMPANY (US) | 1996-12-18 | — | — | EP | disclosed |
| EP-0656209-A2 | Melatonin derivatives for use in treating desynchronization disorders | ELI LILLY AND COMPANY (US) | 1995-06-07 | — | — | EP | disclosed |
| EP-0655243-A2 | Melatonin derivatives for use in treating sleep disorders | ELI LILLY AND COMPANY (US) | 1995-05-31 | — | — | EP | disclosed |
| US-4997845-A | β-alkylmelatonins as ovulation inhibitors | ELI LILLY AND COMPANY (US) | 1991-03-05 | — | — | US | disclosed |