Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 13/20 | 0.64 |
| ▸ | DRD2 | P14416 | 9/20 | 0.64 |
| ▸ | HTR1A | P08908 | 4/20 | 0.57 |
| ▸ | HTR2A | P28223 | 4/20 | 0.57 |
| ▸ | HTR2C | P28335 | 2/20 | 0.57 |
| ▸ | DRD4 | P21917 | 1/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.53 |
| ▸ | HPGDS | O60760 | 1/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.49 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.49 |
| ▸ | HRH1 | P35367 | 1/20 | 0.49 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7052921 | 0.87 | DRD2 (0.70) | DRD3DRD2HTR1AHTR2AHTR2C | |
| SCHEMBL7052681 | 0.84 | DRD3 (0.67) | DRD3DRD2DRD4ADRA1A | |
| SCHEMBL7050873 | 0.82 | DRD2 (0.67) | DRD3DRD2HTR1AHTR2AHTR2C | |
| SCHEMBL7059254 | 0.82 | DRD3 (0.65) | DRD3DRD2HTR1AHTR2AHTR2C | |
| SCHEMBL7055012 | 0.81 | DRD2 (0.65) | DRD3DRD2HTR1AHTR2AHTR2C | |
| SCHEMBL7056313 | 0.79 | DRD3 (0.73) | DRD3DRD2HTR1AHTR2AHTR2C | |
| SCHEMBL16462988 | 0.78 | DRD2 (1.00) | DRD3DRD2 | |
| SCHEMBL7056283 | 0.77 | DRD2 (0.76) | DRD3DRD2HTR1AHTR2AHTR2C | |
| SCHEMBL14006248 | 0.77 | CHRNA7 (0.72) | DRD3DRD2HTR1AHTR2AHTR2C | |
| SCHEMBL4911901 | 0.76 | CHRNA7 (0.74) | DRD3DRD2HTR1AHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003028728-A1 | 4-(4-SUBSTITUTED PIPERAZINYL-1YL)-BUTYLCARBOXAMIDES AS D3 DOPAMINE SUBTYPE SELECTIVE LIGANDS | Richter Gedeon Vegyészeti Gyár Rt. (HU) | 2003-04-10 | — | — | WO | disclosed |