Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT1 | Q99873 | 4/20 | 0.44 |
| ▸ | F2 | P00734 | 3/20 | 0.44 |
| ▸ | PLG | P00747 | 2/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.44 |
| ▸ | PLAU | P00749 | 2/20 | 0.44 |
| ▸ | PLAT | P00750 | 1/20 | 0.44 |
| ▸ | KLK1 | P06870 | 1/20 | 0.44 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.41 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 2/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | TTR | P02766 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22924252 | 0.82 | ALOX5 (0.48) | — | |
| SCHEMBL12348359 | 0.80 | PRMT1 (0.58) | PRMT1F2PLGPRSS1PLAU | |
| Hydrochloric Acid SCHEMBL7766605 | 0.78 | PRMT1 (0.56) | PRMT1F2PLGPRSS1PLAU | |
| SCHEMBL11575253 | 0.71 | TTR (0.45) | HTR2BTTR | |
| SCHEMBL3368604 | 0.69 | MEN1 (0.55) | F2PLGPRSS1PLAUPLAT | |
| SCHEMBL21926432 | 0.69 | ALOX5 (0.56) | F2PLGPRSS1PLAUPLAT | |
| Hydrochloric Acid SCHEMBL29213647 | 0.68 | KMT2A (0.53) | F2PLGPRSS1PLAUPLAT | |
| Hydrochloric Acid SCHEMBL28919945 | 0.68 | ALOX5 (0.56) | PRMT1F2PLGPRSS1PLAU | |
| SCHEMBL20793973 | 0.67 | ALOX5 (0.45) | HTR2B | |
| SCHEMBL23627157 | 0.66 | ALOX5 (0.39) | F2PLGF10HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1105381-A1 | DICATIONIC DIBENZOFURAN AND DIBENZOTHIOPHENE COMPOUNDS AND METHODS OF USE THEREOF | The University of North Carolina at Chapel Hill (US) | 2001-06-13 | — | — | EP | claimed |
| US-6172104-B1 | ADMINISTERING TO TREAT PNEUMOCYSTIS CARINII PNEUMONIA | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | 2001-01-09 | — | — | US | claimed |
| WO-2000010990-A2 | DICATIONIC DIBENZOFURAN AND DIBENZOTHIOPHENE COMPOUNDS AND METHODS OF USE THEREOF | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2000-03-02 | — | — | WO | claimed |
| EP-1105381-B1 | DIBENZOTHIOPHENE COMPOUNDS AND METHODS OF USE THEREOF | UNIV NORTH CAROLINA (US) | 2003-05-02 | — | — | EP | disclosed |
| EP-1105381-A1 | DICATIONIC DIBENZOFURAN AND DIBENZOTHIOPHENE COMPOUNDS AND METHODS OF USE THEREOF | The University of North Carolina at Chapel Hill (US) | 2001-06-13 | — | — | EP | disclosed |
| US-6172104-B1 | ADMINISTERING TO TREAT PNEUMOCYSTIS CARINII PNEUMONIA | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | 2001-01-09 | — | — | US | disclosed |
| WO-2000010990-A2 | DICATIONIC DIBENZOFURAN AND DIBENZOTHIOPHENE COMPOUNDS AND METHODS OF USE THEREOF | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2000-03-02 | — | — | WO | disclosed |