Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | DAO | P14920 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | PEPD | P12955 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26983703 | 0.81 | DAO (0.48) | GAAPKMALOX15HSD17B10CES2 | |
| SCHEMBL11191679 | 0.79 | HSD17B10 (0.72) | GAAPKMALOX15HSD17B10CES2 | |
| SCHEMBL27989047 | 0.76 | GAA (0.45) | GAAPKMALOX15HSD17B10CES2 | |
| SCHEMBL5550842 | 0.75 | NPC1 (0.58) | GAAPKMALOX15HSD17B10DAO | |
| SCHEMBL24670530 | 0.71 | MAPT (0.45) | GAAALOX15HSD17B10KMT2ANPC1 | |
| SCHEMBL24670532 | 0.71 | NPC1 (0.53) | GAAKMT2ANPC1RAB9AKDM4E | |
| SCHEMBL5554805 | 0.71 | GAA (0.44) | GAAPKMALOX15HSD17B10KMT2A | |
| SCHEMBL5526071 | 0.69 | CYP1A2 (0.70) | KMT2ANPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL16644205 | 0.69 | GAA (0.42) | GAAPKMALOX15HSD17B10CES2 | |
| SCHEMBL28309815 | 0.67 | CNR1 (0.59) | KMT2ANPC1RAB9AKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003029241-A1 | CHK1 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-04-10 | — | — | WO | disclosed |