SCHEMBL7057353

SCHEMBL7057353

OCC=CC(O)c1ccc(F)cc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AOC3 Q16853 1/20 0.38
MRGPRX1 Q96LB2 1/20 0.35
KDM4E B2RXH2 1/20 0.34
IDO1 P14902 2/20 0.33
TDO2 P48775 2/20 0.33
HDAC3 O15379 1/20 0.33
HDAC4 P56524 1/20 0.33
HDAC1 Q13547 1/20 0.33
HDAC7 Q8WUI4 1/20 0.33
HDAC2 Q92769 1/20 0.33
HDAC10 Q969S8 1/20 0.33
HDAC11 Q96DB2 1/20 0.33
HDAC8 Q9BY41 1/20 0.33
HDAC6 Q9UBN7 1/20 0.33
HDAC9 Q9UKV0 1/20 0.33
HDAC5 Q9UQL6 1/20 0.33
ALOX15 P16050 1/20 0.33
TSHR P16473 1/20 0.33
APEX1 P27695 1/20 0.33
GABBR2 O75899 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7057351 1.00 AOC3 (0.38) AOC3MRGPRX1KDM4EIDO1TDO2
SCHEMBL10999062 0.80 STAT3 (0.35) ALOX15TSHRAPEX1
SCHEMBL7059435 0.80 TSHR (0.51) AOC3HDAC4HDAC7HDAC5ALOX15
SCHEMBL7059432 0.80 TSHR (0.51) AOC3HDAC4HDAC7HDAC5ALOX15
SCHEMBL10999065 0.80 STAT3 (0.35) ALOX15TSHRAPEX1
SCHEMBL11001287 0.79 LMNA (0.40) AOC3KDM4ETSHRTRPA1
SCHEMBL11001286 0.79 LMNA (0.40) AOC3KDM4ETSHRTRPA1
SCHEMBL10671874 0.78 AOC3 (0.45) AOC3KDM4E
SCHEMBL10671870 0.78 AOC3 (0.45) AOC3KDM4E
SCHEMBL16070721 0.76 HDAC8 (0.31) HDAC8ALOX15TSHRAPEX1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1053218-B1 DIOL COMPOUNDS AS INTERMEDIATES FOR PREPARING ANTIMYCOTIC COMPOUNDS ZAMBON SPA (IT) 2003-05-07 EP disclosed