SCHEMBL7057484

SCHEMBL7057484

CCCCOC(=O)Nc1cccc(CC)n1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 2/20 0.58
CHRNB4 P30926 2/20 0.58
CHRNA3 P32297 2/20 0.58
CHRNA4 P43681 2/20 0.58
RAB9A P51151 10/20 0.51
HPGD P15428 5/20 0.51
LMNA P02545 2/20 0.51
SMN1; SMN2 Q16637 8/20 0.50
NPC1 O15118 8/20 0.50
CYP1A2 P05177 4/20 0.50
CYP2C19 P33261 4/20 0.50
ALDH1A1 P00352 2/20 0.50
NFKB1 P19838 1/20 0.50
STAT1 P42224 1/20 0.50
NFKB2 Q00653 1/20 0.50
RELA Q04206 1/20 0.50
L3MBTL1 Q9Y468 2/20 0.49
CYP2C9 P11712 2/20 0.48
MAPT P10636 2/20 0.47
TP53 P04637 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10084279 0.96 CHRNB2 (0.54) CHRNB2CHRNB4CHRNA3CHRNA4RAB9A
SCHEMBL10082517 0.92 CHRNB2 (0.61) CHRNB2CHRNB4CHRNA3CHRNA4RAB9A
SCHEMBL30395909 0.90 RAB9A (0.50) CHRNB2CHRNB4CHRNA3CHRNA4RAB9A
SCHEMBL14879934 0.90 RAB9A (0.50) CHRNB2CHRNB4CHRNA3CHRNA4RAB9A
SCHEMBL5352818 0.89 RAB9A (0.49) CHRNB2CHRNB4CHRNA3CHRNA4RAB9A
SCHEMBL5347879 0.87 RAB9A (0.50) CHRNB2CHRNB4CHRNA3CHRNA4RAB9A
SCHEMBL10084528 0.86 CHRNB2 (0.55) CHRNB2CHRNB4CHRNA3CHRNA4CYP1A2
SCHEMBL5348279 0.86 RAB9A (0.46) CHRNB2CHRNB4CHRNA3CHRNA4RAB9A
SCHEMBL5347545 0.84 RAB9A (0.64) CHRNB2CHRNB4CHRNA3CHRNA4RAB9A
SCHEMBL3632906 0.83 RAB9A (0.51) CHRNB2CHRNB4CHRNA3CHRNA4RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1309589-A2 UREA COMPOUNDS AND METHODS OF USES Amgen Inc. (US) 2003-05-14 EP disclosed
WO-2002014311-A2 UREA COMPOUNDS AND METHODS OF USES AMGEN INC. (US) 2002-02-21 WO disclosed