Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 11/20 | 0.59 |
| ▸ | DRD3 | P35462 | 9/20 | 0.59 |
| ▸ | DRD4 | P21917 | 6/20 | 0.59 |
| ▸ | FAAH | O00519 | 1/20 | 0.56 |
| ▸ | HTR2A | P28223 | 2/20 | 0.56 |
| ▸ | HTR1A | P08908 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.53 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7053721 | 0.80 | DRD3 (0.72) | DRD2DRD3DRD4FAAHHTR2A | |
| SCHEMBL7051897 | 0.76 | DRD2 (0.69) | DRD2DRD3HTR2AHTR1AMEN1 | |
| SCHEMBL7114888 | 0.73 | DRD2 (0.73) | DRD2DRD3DRD4 | |
| SCHEMBL7054878 | 0.72 | DRD2 (0.64) | DRD2DRD3DRD4HTR2AHTR1A | |
| SCHEMBL13808687 | 0.72 | KMT2A (0.55) | MEN1POLBRAB9AKMT2AHDAC3 | |
| SCHEMBL16403787 | 0.72 | DRD3 (1.00) | DRD2DRD3DRD4FAAHHTR2A | |
| SCHEMBL9650947 | 0.72 | DRD3 (0.75) | DRD2DRD3DRD4HTR2AHTR1A | |
| SCHEMBL5504452 | 0.70 | DRD3 (1.00) | DRD2DRD3DRD4HTR2AHTR1A | |
| SCHEMBL8146978 | 0.70 | KMT2A (0.82) | MEN1POLBRAB9AKMT2AHDAC3 | |
| SCHEMBL5504457 | 0.70 | DRD2 (0.70) | DRD2DRD3DRD4HTR2AHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003028728-A1 | 4-(4-SUBSTITUTED PIPERAZINYL-1YL)-BUTYLCARBOXAMIDES AS D3 DOPAMINE SUBTYPE SELECTIVE LIGANDS | Richter Gedeon Vegyészeti Gyár Rt. (HU) | 2003-04-10 | — | — | WO | disclosed |