Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 11/20 | 0.69 |
| ▸ | HTR1A | P08908 | 9/20 | 0.69 |
| ▸ | HTR2A | P28223 | 9/20 | 0.69 |
| ▸ | DRD3 | P35462 | 12/20 | 0.65 |
| ▸ | HTR2C | P28335 | 5/20 | 0.65 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7053098 | 0.85 | RAB9A (0.53) | DRD2HTR1AHTR2ADRD3HTR2C | |
| SCHEMBL7053721 | 0.81 | DRD3 (0.72) | DRD2HTR1AHTR2ADRD3ADRA1A | |
| SCHEMBL4525593 | 0.79 | DRD2 (1.00) | DRD2HTR1AHTR2ADRD3HTR2C | |
| SCHEMBL7057729 | 0.76 | DRD2 (0.59) | DRD2HTR1AHTR2ADRD3MEN1 | |
| SCHEMBL7044389 | 0.75 | DRD2 (0.68) | DRD2HTR1AHTR2ADRD3ADRA1A | |
| SCHEMBL8146978 | 0.74 | KMT2A (0.82) | MEN1POLBRAB9AKMT2AHDAC3 | |
| SCHEMBL7052921 | 0.74 | DRD2 (0.70) | DRD2HTR1AHTR2ADRD3HTR2C | |
| SCHEMBL16461861 | 0.74 | DRD2 (1.00) | DRD2HTR1AHTR2ADRD3HTR2C | |
| SCHEMBL7054921 | 0.74 | DRD2 (0.63) | DRD2HTR1AHTR2ADRD3HTR2C | |
| SCHEMBL7058045 | 0.73 | DRD2 (0.75) | DRD2HTR1AHTR2ADRD3HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003028728-A1 | 4-(4-SUBSTITUTED PIPERAZINYL-1YL)-BUTYLCARBOXAMIDES AS D3 DOPAMINE SUBTYPE SELECTIVE LIGANDS | Richter Gedeon Vegyészeti Gyár Rt. (HU) | 2003-04-10 | — | — | WO | disclosed |