Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.59 |
| ▸ | MEN1 | O00255 | 4/20 | 0.59 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | MMP1 | P03956 | 1/20 | 0.51 |
| ▸ | MMP2 | P08253 | 1/20 | 0.51 |
| ▸ | MMP9 | P14780 | 1/20 | 0.51 |
| ▸ | MMP8 | P22894 | 1/20 | 0.51 |
| ▸ | MMP13 | P45452 | 1/20 | 0.51 |
| ▸ | F2 | P00734 | 2/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.47 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.47 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25426560 | 0.83 | KMT2A (0.59) | KMT2AMEN1CA1CA2MMP1 | |
| SCHEMBL9340103 | 0.83 | KMT2A (0.59) | KMT2AMEN1CA1CA2MMP1 | |
| SCHEMBL6367042 | 0.83 | KMT2A (0.59) | KMT2AMEN1CA1CA2MMP1 | |
| SCHEMBL7896686 | 0.82 | KMT2A (0.68) | KMT2AMEN1CA1CA2MMP1 | |
| SCHEMBL12751034 | 0.80 | KMT2A (0.66) | KMT2AMEN1CA1CA2MMP1 | |
| SCHEMBL11260836 | 0.79 | KMT2A (0.63) | KMT2AMEN1CA1CA2MMP1 | |
| SCHEMBL14613962 | 0.79 | KMT2A (0.63) | KMT2AMEN1CA1CA2MMP1 | |
| SCHEMBL9948638 | 0.79 | KMT2A (0.63) | KMT2AMEN1CA1CA2MMP1 | |
| SCHEMBL4580867 | 0.78 | KMT2A (0.68) | KMT2AMEN1CA1CA2MMP1 | |
| SCHEMBL2362856 | 0.78 | TXNRD1 (0.54) | KMT2AMEN1CA1CA2MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003026666-A1 | 2-PHENYLAMINO-4- (5-PYRAZOLYLAMINO)-PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS, IN PARTICULAR, AS SRC KINASE INHIBITORS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |