Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TXNRD1 | Q16881 | 4/20 | 0.54 |
| ▸ | GSR | P00390 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | MMP1 | P03956 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | MMP8 | P22894 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.43 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.43 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.43 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9453001 | 1.00 | TXNRD1 (0.54) | TXNRD1GSRKMT2AMEN1PKM | |
| SCHEMBL6367042 | 0.87 | KMT2A (0.59) | KMT2AMEN1PKMALDH1A1CA1 | |
| SCHEMBL14740564 | 0.85 | KMT2A (0.53) | TXNRD1GSRKMT2AMEN1PKM | |
| SCHEMBL12751034 | 0.82 | KMT2A (0.66) | KMT2AMEN1PKMALDH1A1CA1 | |
| SCHEMBL11332743 | 0.81 | KMT2A (0.49) | KMT2AMEN1PKMALDH1A1CA1 | |
| SCHEMBL7033755 | 0.80 | TXNRD1 (0.60) | TXNRD1GSRKMT2AMEN1PKM | |
| SCHEMBL7896686 | 0.80 | KMT2A (0.68) | KMT2AMEN1PKMALDH1A1CA1 | |
| SCHEMBL14997056 | 0.79 | KMT2A (0.50) | KMT2AMEN1PKMALDH1A1CA1 | |
| SCHEMBL163300 | 0.79 | ALDH1A1 (0.57) | TXNRD1GSRKMT2AMEN1ALDH1A1 | |
| SCHEMBL8711063 | 0.79 | KMT2A (0.50) | TXNRD1KMT2AMEN1PKMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2083764-B1 | N-SUBSTITUTED MONOMERS AND POLYMERS | UNIV RUTGERS (US) | 2015-08-26 | — | — | EP | disclosed |
| EP-2718283-A1 | INDAZOLE- AND PYRROLOPYRIDINE-DERIVATIVE AND PHARMACEUTICAL USE THEREOF | Dainippon Sumitomo Pharma Co., Ltd. (JP) | 2014-04-16 | — | — | EP | disclosed |
| US-20140057895-A1 | INDAZOLE- AND PYRROLOPYRIDINE-DERIVATIVE AND PHARMACEUTICAL USE THEREOF | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2014-02-27 | — | — | US | disclosed |
| EP-2079491-B1 | N-SUBSTITUTED MONOMERS AND POLYMERS | REVA MEDICAL INC (US) | 2013-02-27 | — | — | EP | disclosed |
| WO-2012169649-A1 | INDAZOLE- AND PYRROLOPYRIDINE-DERIVATIVE AND PHARMACEUTICAL USE THEREOF | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2012-12-13 | — | — | WO | disclosed |
| US-8288590-B2 | N-substituted monomers and polymers | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2012-10-16 | — | — | US | disclosed |
| US-20110269848-A1 | N-SUBSTITUTED MONOMERS AND POLYMERS | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2011-11-03 | — | — | US | disclosed |
| US-8034365-B2 | Polymer substituted with amide or thioamide groups; vascular stents, bioreabsorbable polymers | REVA MEDICAL, INC. (US) | 2011-10-11 | — | — | US | disclosed |
| US-8008528-B2 | Polymers substituted with amide or thioamide groups; vascular stents; bioreabsorable polymer; low viscosity melt | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2011-08-30 | — | — | US | disclosed |
| EP-2083764-A2 | N-SUBSTITUTED MONOMERS AND POLYMERS | Rutgers, The State University (US) | 2009-08-05 | — | — | EP | disclosed |
| EP-2079491-A2 | N-SUBSTITUTED MONOMERS AND POLYMERS | Reva Medical, Inc. (US) | 2009-07-22 | — | — | EP | disclosed |
| WO-2008100346-A2 | N-SUBSTITUTED MONOMERS AND POLYMERS | REVA MEDICAL, INC. (US) | 2008-08-21 | — | — | WO | disclosed |
| US-20080187567-A1 | N-SUBSTITUTED MONOMERS AND POLYMERS | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | 2008-08-07 | — | — | US | disclosed |
| WO-2008082738-A2 | N-SUBSTITUTED MONOMERS AND POLYMERS | RUTGERS, THE STATE UNIVERSITY (US) | 2008-07-10 | — | — | WO | disclosed |
| US-20080112999-A1 | N-SUBSTITUTED MONOMERS AND POLYMERS | REVA MEDICAL, INC. (US) | 2008-05-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110269848-A1 | N-SUBSTITUTED MONOMERS AND POLYMERS | NANS, NCL, PNISR | TXNRD1 4744/4885GSR 3244/4885KMT2A 3118/4885 |
| US-20080187567-A1 | N-SUBSTITUTED MONOMERS AND POLYMERS | NANS, NCL, PNISR | TXNRD1 4744/4885GSR 3244/4885KMT2A 3118/4885 |
| US-20140057895-A1 | INDAZOLE- AND PYRROLOPYRIDINE-DERIVATIVE AND PHARMACEUTICAL USE THEREOF | HTR4, HTR3B, HTR3A | TXNRD1 4043/4885GSR 1678/4885KMT2A 4241/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.