Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 8/20 | 0.40 |
| ▸ | HTR2B | P41595 | 5/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | RXRB | P28702 | 1/20 | 0.36 |
| ▸ | RXRG | P48443 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16586800 | 0.81 | HTR2C (0.44) | OPRM1HTR2CHTR2BHTR2AHCRTR1 | |
| SCHEMBL16586799 | 0.81 | HTR2C (0.44) | OPRM1HTR2CHTR2BHTR2AHCRTR1 | |
| SCHEMBL19262115 | 0.81 | HTR2C (0.44) | OPRM1HTR2CHTR2BHTR2AHCRTR1 | |
| SCHEMBL18016757 | 0.81 | HTR2C (0.44) | OPRM1HTR2CHTR2BHTR2AHCRTR1 | |
| SCHEMBL15254790 | 0.79 | HTR2C (0.63) | HTR2CHTR2BHTR2A | |
| SCHEMBL16590861 | 0.79 | HTR2C (0.49) | HTR2CHTR2BHTR2AHCRTR1HCRTR2 | |
| SCHEMBL15254788 | 0.79 | HTR2C (0.63) | HTR2CHTR2BHTR2A | |
| SCHEMBL18016882 | 0.75 | HTR2C (0.49) | OPRM1HTR2CHTR2BHTR2AHCRTR1 | |
| SCHEMBL17189661 | 0.74 | DRD2 (0.44) | OPRM1DRD2GAARXRARXRB | |
| SCHEMBL2969140 | 0.74 | DRD2 (0.44) | OPRM1DRD2GAARXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490317-A1 | GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003082787-A1 | GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2003-10-09 | — | — | WO | disclosed |