Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 8/20 | 0.48 |
| ▸ | CDK5R1 | Q15078 | 8/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.36 |
| ▸ | CDK2 | P24941 | 2/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.36 |
| ▸ | PRKCA | P17252 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | GBA1 | P04062 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | CCR4 | P51679 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5341200 | 0.87 | CDK5 (0.60) | CDK5CDK5R1RAB9ACCNA2CDK2 | |
| SCHEMBL5339186 | 0.86 | CDK5 (0.53) | CDK5CDK5R1RAB9ACCNA2CDK2 | |
| SCHEMBL5345614 | 0.85 | CDK5 (0.47) | CDK5CDK5R1RAB9ASYKCCNA2 | |
| SCHEMBL5354095 | 0.84 | CDK5 (0.46) | CDK5CDK5R1RAB9ASYKCCNA2 | |
| SCHEMBL5341715 | 0.83 | CDK5 (0.47) | CDK5CDK5R1RAB9ANPC1TP53 | |
| SCHEMBL5347914 | 0.83 | CDK5 (0.46) | CDK5CDK5R1RAB9ASYKCCNA2 | |
| SCHEMBL6629791 | 0.78 | CDK5 (0.54) | CDK5CDK5R1CCNA2CDK2CCNA1 | |
| SCHEMBL14558383 | 0.77 | CDK5 (0.55) | CDK5CDK5R1RAB9ASYKCHRNB2 | |
| SCHEMBL14558395 | 0.75 | CDK5 (0.53) | CDK5CDK5R1RAB9ACCNA2CDK2 | |
| SCHEMBL5689495 | 0.75 | CDK5 (0.65) | CDK5CDK5R1RAB9ASYKCHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1309589-A2 | UREA COMPOUNDS AND METHODS OF USES | Amgen Inc. (US) | 2003-05-14 | — | — | EP | disclosed |
| WO-2002014311-A2 | UREA COMPOUNDS AND METHODS OF USES | AMGEN INC. (US) | 2002-02-21 | — | — | WO | disclosed |