Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Prednisolone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 10/20 | 0.96 |
| ▸ | HIF1A | Q16665 | 9/20 | 0.96 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.96 |
| ▸ | PGR | P06401 | 5/20 | 0.96 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.96 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.96 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.96 |
| ▸ | SERPINA6 | P08185 | 2/20 | 0.96 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.96 |
| ▸ | TNF | P01375 | 1/20 | 0.96 |
| ▸ | IL6 | P05231 | 1/20 | 0.96 |
| ▸ | AR | P10275 | 1/20 | 0.96 |
| ▸ | GLUL | P15104 | 1/20 | 0.96 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.96 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.96 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.68 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.68 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.68 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.68 |
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Prednisolone SCHEMBL6566835 | 0.98 | NR3C1 (1.00) | NR3C1HIF1AHSD17B10PGRCYP3A4 | |
| Prednisolone SCHEMBL12396679 | 0.98 | NR3C1 (1.00) | NR3C1HIF1AHSD17B10PGRCYP3A4 | |
| Prednisolone SCHEMBL4449434 | 0.98 | NR3C1 (1.00) | NR3C1HIF1AHSD17B10PGRCYP3A4 | |
| Prednisolone SCHEMBL765329 | 0.98 | NR3C1 (1.00) | NR3C1HIF1AHSD17B10PGRCYP3A4 | |
| Prednisolone SCHEMBL11413677 | 0.98 | NR3C1 (1.00) | NR3C1HIF1AHSD17B10PGRCYP3A4 | |
| Prednisolone SCHEMBL23863778 | 0.98 | NR3C1 (1.00) | NR3C1HIF1AHSD17B10PGRCYP3A4 | |
| Prednisolone SCHEMBL13044469 | 0.98 | NR3C1 (1.00) | NR3C1HIF1AHSD17B10PGRCYP3A4 | |
| Prednisolone SCHEMBL14420691 | 0.98 | NR3C1 (1.00) | NR3C1HIF1AHSD17B10PGRCYP3A4 | |
| Prednisolone SCHEMBL2737385 | 0.98 | NR3C1 (1.00) | NR3C1HIF1AHSD17B10PGRCYP3A4 | |
| Prednisolone SCHEMBL2597917 | 0.98 | NR3C1 (1.00) | NR3C1HIF1AHSD17B10PGRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116963723-A | Pharmaceutical compositions with reduced side effects and methods of use thereof | TLC生物医药公司 | 2023-10-27 | — | — | CN | claimed |
| CN-113820416-A | Method for simultaneously detecting multiple stimulants in animal food | 石家庄海关技术中心 | 2021-12-21 | — | — | CN | claimed |
| CN-113557020-A | Compositions comprising CRAC inhibitors and corticosteroids and methods of use thereof | 瑞真药业公司 | 2021-10-26 | — | — | CN | claimed |
| CN-112334128-A | Pharmaceutical composition containing dexpanthenol and polyhexamethylene guanidine | 巴伐利亚专利联盟有限责任公司 | 2021-02-05 | — | — | CN | claimed |
| CN-111788185-A | Diaryl substituted 6,5 fused ring compounds as C5a inhibitors | 凯莫森特里克斯股份有限公司 | 2020-10-16 | — | — | CN | claimed |
| CN-111417730-A | Diagnostic method | 托雷莫治疗股份公司 | 2020-07-14 | — | — | CN | claimed |
| CN-111032658-A | 5-5 fused rings as C5a inhibitors | 凯莫森特里克斯股份有限公司 | 2020-04-17 | — | — | CN | claimed |
| CN-110997674-A | 6-5 fused rings as C5a inhibitors | 凯莫森特里克斯股份有限公司 | 2020-04-10 | — | — | CN | claimed |
| CN-118215679-A | IL-13 antibodies for the treatment of atopic dermatitis | 德米拉公司 | 2024-06-18 | — | — | CN | disclosed |
| CN-118103396-A | IL-13 antibodies for the treatment of atopic dermatitis | 德米拉公司 | 2024-05-28 | — | — | CN | disclosed |
| CN-116963723-A | Pharmaceutical compositions with reduced side effects and methods of use thereof | TLC生物医药公司 | 2023-10-27 | — | — | CN | disclosed |
| CN-116963752-A | Combination therapy for inflammatory disorders of the joint | 赛瓦图斯有限公司 | 2023-10-27 | — | — | CN | disclosed |
| CN-113365673-B | High strength porous materials for controlled release | 阿塞斯血管有限公司 | 2022-10-28 | — | — | CN | disclosed |
| CN-115087664-A | IL-2R beta gamma c binding compounds | 麦地金公司 | 2022-09-20 | — | — | CN | disclosed |
| US-6328991-B1 | Composition and method for prevention of sexually transmitted diseases, including aids | MYHLING JOHN (US) | 2001-12-11 | — | — | US | disclosed |
| US-5527534-A | USER-CONTROLLED RELEASE OF DRUG CONTAINED IN SATURATED SPONGE. A TRUNCATED SPHERE OR TAMPON; FOR DELIVERING CONTRACEPTIVES, ANTIBIOTICS, HORMONES, ANTIINFLAMMATORY AGENTS OR CLEANSING AGENTS | GYNETECH LABORATORIES, LTD. (US) | 1996-06-18 | — | — | US | disclosed |
| EP-0665733-A4 | VAGINAL SPONGE DELIVERY SYSTEM. | GYNETECH LAB INC (US) | 1996-04-10 | — | — | EP | disclosed |
| EP-0665733-A1 | VAGINAL SPONGE DELIVERY SYSTEM | GYNETECH LABORATORIES, INC. (US) | 1995-08-09 | — | — | EP | disclosed |
| WO-1994008536-A9 | VAGINAL SPONGE DELIVERY SYSTEM | — | 1994-08-04 | — | — | WO | disclosed |
| WO-1994008536-A1 | VAGINAL SPONGE DELIVERY SYSTEM | GYNETECH LABORATORIES, INC. (US) | 1994-04-28 | — | — | WO | disclosed |