Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 6/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | ERN1 | O75460 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7062491 | 0.89 | ALDH1A1 (0.44) | MAPTCYP2C9CYP2C19CYP1A2CYP3A4 | |
| SCHEMBL7060986 | 0.84 | MAPT (0.40) | MAPTCYP2C9CYP2C19CYP1A2CYP3A4 | |
| SCHEMBL7060989 | 0.84 | MAPT (0.40) | MAPTCYP2C9CYP2C19CYP1A2CYP3A4 | |
| SCHEMBL7066729 | 0.83 | ALDH1A1 (0.53) | MAPTCYP2C9CYP2C19CYP1A2CYP3A4 | |
| SCHEMBL5571262 | 0.83 | MAPT (0.42) | MAPTCYP2C9CYP2C19CYP1A2CYP3A4 | |
| SCHEMBL7062973 | 0.82 | MAPT (0.43) | MAPTCYP2C9CYP2C19CYP1A2CYP3A4 | |
| SCHEMBL7066419 | 0.82 | ALDH1A1 (0.40) | MAPTCYP2C9CYP2C19CYP1A2CYP3A4 | |
| SCHEMBL7062256 | 0.82 | ALDH1A1 (0.41) | MAPTCYP2C9CYP2C19CYP1A2CYP3A4 | |
| SCHEMBL915958 | 0.82 | ALDH1A1 (0.44) | MAPTCYP2C9CYP2C19CYP1A2CYP3A4 | |
| SCHEMBL5571227 | 0.82 | MAPT (0.42) | MAPTCYP2C9CYP2C19CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1313461-A2 | THE USE OF BENZYLIDENEAMINOGUANIDINES AND HYDROXYGUANIDINES AS MELANOCORTIN RECEPTOR LIGANDS | Melacure Therapeutics AB (SE) | 2003-05-28 | — | — | EP | disclosed |
| WO-2002011715-A2 | THE USE OF BENZYLIDENEAMINOGUANIDINES AND HYDROXYGUANIDINES AS MELANOCORTIN RECEPTOR LIGANDS | MELACURE THERAPEUTICS AB (SE) | 2002-02-14 | — | — | WO | disclosed |