Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.36 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.36 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.36 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.36 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 6/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7065007 | 0.91 | MAPT (0.43) | MAPTCYP2C9CYP2C19CYP1A2CYP3A4 | |
| SCHEMBL5571262 | 0.89 | MAPT (0.42) | MAPTCYP2C9CYP2C19CYP1A2CYP3A4 | |
| SCHEMBL5571227 | 0.86 | MAPT (0.42) | MAPTCYP2C9CYP2C19CYP1A2CYP3A4 | |
| SCHEMBL7065975 | 0.85 | MAPT (0.39) | MAPTCYP2C9CYP2C19CYP1A2CYP3A4 | |
| SCHEMBL7062966 | 0.85 | MAPT (0.43) | MAPTCYP2C9CYP2C19CYP1A2CYP3A4 | |
| SCHEMBL7062970 | 0.85 | MAPT (0.43) | MAPTCYP2C9CYP2C19CYP1A2CYP3A4 | |
| SCHEMBL7060993 | 0.82 | MAPT (0.42) | MAPTCYP2C9CYP2C19CYP1A2CYP3A4 | |
| SCHEMBL7062491 | 0.82 | ALDH1A1 (0.44) | MAPTCYP2C9CYP2C19CYP1A2CYP3A4 | |
| SCHEMBL7066074 | 0.82 | MAPT (0.36) | MAPTALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL7065013 | 0.82 | ALDH1A1 (0.39) | MAPTALDH1A1KMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1313461-A2 | THE USE OF BENZYLIDENEAMINOGUANIDINES AND HYDROXYGUANIDINES AS MELANOCORTIN RECEPTOR LIGANDS | Melacure Therapeutics AB (SE) | 2003-05-28 | — | — | EP | disclosed |
| WO-2002011715-A2 | THE USE OF BENZYLIDENEAMINOGUANIDINES AND HYDROXYGUANIDINES AS MELANOCORTIN RECEPTOR LIGANDS | MELACURE THERAPEUTICS AB (SE) | 2002-02-14 | — | — | WO | disclosed |