Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 4/20 | 0.38 |
| ▸ | SELP | P16109 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | PTPN7 | P35236 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HMGCR | P04035 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3080727 | 0.91 | — | — | |
| SCHEMBL6159056 | 0.83 | HDAC3 (0.55) | LMNAHDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL29315161 | 0.83 | HDAC3 (0.55) | LMNAHDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL5909483 | 0.83 | HDAC3 (0.55) | LMNAHDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL5909431 | 0.83 | HDAC3 (0.55) | LMNAHDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL12333287 | 0.83 | HDAC3 (0.55) | LMNAHDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL10816049 | 0.81 | — | — | |
| SCHEMBL15268183 | 0.81 | CYP1A2 (0.57) | LMNAHDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL29922517 | 0.81 | CYP1A2 (0.57) | LMNAHDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL7753090 | 0.81 | LMNA (0.57) | LMNAHDAC3HDAC1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003033516-A1 | 8β -SUBSTITUTED-11β -ARYL-ESTRA-1,3,5(10)-TRIENE DERIVATIVES | SCHERING AKTIENGESELLSCHAFT (DE) | 2003-04-24 | — | — | WO | claimed |