SCHEMBL7062871

SCHEMBL7062871

c1ccc2c(c1)CCCCOCC2

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.62
ALDH1A1 P00352 1/20 0.38
CYP2A6 P11509 2/20 0.38
HTR2C P28335 1/20 0.37
DRD2 P14416 2/20 0.37
DRD1 P21728 2/20 0.37
DRD4 P21917 2/20 0.37
DRD5 P21918 2/20 0.37
DRD3 P35462 2/20 0.37
CA12 O43570 1/20 0.36
CA1 P00915 1/20 0.36
CA2 P00918 1/20 0.36
CA9 Q16790 1/20 0.36
HPGD P15428 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
SMN1; SMN2 Q16637 3/20 0.36
LMNA P02545 2/20 0.36
CRHBP P24387 2/20 0.36
CRHR2 Q13324 2/20 0.36
MAOA P21397 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tetrahydrofuran SCHEMBL3265313 0.95 TSHR (0.68) TSHRALDH1A1CYP2A6HTR2CDRD2
SCHEMBL7065615 0.93 TSHR (0.57) TSHRCYP2A6HTR2CDRD2DRD1
SCHEMBL30988915 0.88 TSHR (0.57) TSHRALDH1A1CYP2A6HTR2CDRD2
Dioxane SCHEMBL1449342 0.87 TSHR (0.72) TSHRCYP2A6HTR2CDRD2DRD1
SCHEMBL7063876 0.87 TSHR (0.63) TSHRALDH1A1CYP2A6HTR2CDRD2
SCHEMBL2062312 0.87 TSHR (0.53) TSHRCYP2A6HTR2CDRD2DRD1
SCHEMBL24774025 0.85 TSHR (0.60) TSHRALDH1A1CYP2A6HTR2CDRD2
SCHEMBL24772918 0.85 TSHR (0.60) TSHRALDH1A1CYP2A6HTR2CDRD2
SCHEMBL7065665 0.84 TSHR (0.59) TSHRCYP2A6HTR2CDRD2DRD1
SCHEMBL7065340 0.82 TSHR (0.56) TSHRCYP2A6HTR2CDRD2DRD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0901787-B1 Stabilized pharmaceutical composition TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2003-05-28 EP disclosed
EP-0952826-B1 IDEBENONE CONTAINING COMBINATION AGENT FOR TREATING ALZHEIMER'S DISEASE TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2001-11-14 EP disclosed
US-6187340-B1 TABLETS WITH COATINGS THAT PROTECT FROM LIGHT TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2001-02-13 US disclosed
EP-0952826-A1 IDEBENONE CONTAINING COMBINATION AGENT FOR TREATING ALZHEIMER'S DISEASE Takeda Chemical Industries, Ltd. (JP) 1999-11-03 EP disclosed
US-5962535-A SYNERGISTIC MIXTURE OF IDEBENONE AND ACETYLCHOLINESTERASE INHIBITOR TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1999-10-05 US disclosed
EP-0901787-A1 Stabilized pharmaceutical composition Takeda Chemical Industries, Ltd. (JP) 1999-03-17 EP disclosed
WO-1998031356-A1 IDEBENONE CONTAINING COMBINATION AGENT FOR TREATING ALZHEIMER'S DISEASE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1998-07-23 WO disclosed