SCHEMBL7063319

SCHEMBL7063319

O=C(O)C=C(c1ccccc1)c1cccc([N+](=O)[O-])c1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TP53 P04637 1/20 0.63
CES2 O00748 1/20 0.60
CES1 P23141 1/20 0.60
ALDH1A1 P00352 5/20 0.57
TSHR P16473 2/20 0.57
MAPT P10636 3/20 0.54
MEN1 O00255 2/20 0.54
KMT2A Q03164 2/20 0.54
HTT P42858 2/20 0.54
SMN1; SMN2 Q16637 2/20 0.54
MITF O75030 1/20 0.54
HSP90AA1 P07900 1/20 0.54
NPSR1 Q6W5P4 1/20 0.54
MAOB P27338 1/20 0.54
KMO O15229 1/20 0.52
PRSS1 P07477 1/20 0.50
PRSS2 P07478 1/20 0.50
PRSS3 P35030 1/20 0.50
HPGD P15428 1/20 0.50
PTPN1 P18031 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7063316 1.00 TP53 (0.63) TP53CES2CES1ALDH1A1TSHR
SCHEMBL8134880 1.00 TP53 (0.63) TP53CES2CES1ALDH1A1TSHR
SCHEMBL7783945 0.97 TP53 (0.67) TP53CES2CES1ALDH1A1TSHR
SCHEMBL28768468 0.88 TP53 (0.59) TP53CES2CES1ALDH1A1TSHR
SCHEMBL28768467 0.87 TP53 (0.58) TP53CES2CES1ALDH1A1TSHR
SCHEMBL7852918 0.85 CES1 (0.66) CES2CES1ALDH1A1TSHRMAPT
SCHEMBL7842423 0.85 CES1 (0.66) CES2CES1ALDH1A1TSHRMAPT
SCHEMBL7842426 0.85 CES1 (0.66) CES2CES1ALDH1A1TSHRMAPT
SCHEMBL22208457 0.81 TP53 (0.58) TP53CES2CES1ALDH1A1TSHR
SCHEMBL5757238 0.81 ALDH1A1 (0.66) TP53CES2CES1ALDH1A1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1314721-A1 NOVEL PROPENOHYDROXAMIC ACID DERIVATIVES WAKUNAGA PHARMACEUTICAL CO., LTD. (JP) 2003-05-28 EP disclosed
EP-1091958-A1 SALTS OF PAROXETINE SMITHKLINE BEECHAM PLC (GB) 2001-04-18 EP disclosed
EP-0738269-B1 PIPERIDINE DERIVATIVES WITH PAF ANTAGONIST ACTIVITY URIACH & CIA SA J (ES) 2000-04-26 EP disclosed
WO-2000001692-A1 SALTS OF PAROXETINE SMITHKLINE BEECHAM PLC (GB) 2000-01-13 WO disclosed
US-5705504-A PLATELET ACTIVATING FACTOR J. URIACH & CIA, S.A. (ES) 1998-01-06 US disclosed
EP-0738269-A1 NOVEL PIPERIDINE DERIVATIVES WITH PAF ANTAGONIST ACTIVITY J. URIACH & CIA. S.A. (ES) 1996-10-23 EP disclosed
WO-1996022305-A2 MODIFIED PEPTIDES THE WELLCOME FOUNDATION LIMITED (GB) 1996-07-25 WO disclosed
WO-1996014317-A1 NOVEL PIPERIDINE DERIVATIVES WITH PAF ANTAGONIST ACTIVITY J. URIACH & CIA. S.A. (ES) 1996-05-17 WO disclosed
US-4342781-A PREVENTING AND TREATING ALLERGIC BRONCHIAL ASTHMA, RHINITIS AND SKIN DISORDERS PFIZER INC. (US) 1982-08-03 US disclosed