Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.67 |
| ▸ | CES2 | O00748 | 1/20 | 0.64 |
| ▸ | CES1 | P23141 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | TSHR | P16473 | 3/20 | 0.60 |
| ▸ | KMO | O15229 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.53 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.53 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | MITF | O75030 | 1/20 | 0.52 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7063316 | 0.97 | TP53 (0.63) | TP53CES2CES1ALDH1A1TSHR | |
| SCHEMBL8134880 | 0.97 | TP53 (0.63) | TP53CES2CES1ALDH1A1TSHR | |
| SCHEMBL7063319 | 0.97 | TP53 (0.63) | TP53CES2CES1ALDH1A1TSHR | |
| SCHEMBL28768468 | 0.84 | TP53 (0.59) | TP53CES2CES1ALDH1A1TSHR | |
| SCHEMBL2920013 | 0.84 | ALDH1A1 (0.66) | TP53CES2CES1ALDH1A1TSHR | |
| SCHEMBL5757234 | 0.84 | ALDH1A1 (0.66) | TP53CES2CES1ALDH1A1TSHR | |
| SCHEMBL5757238 | 0.84 | ALDH1A1 (0.66) | TP53CES2CES1ALDH1A1TSHR | |
| SCHEMBL28768467 | 0.83 | TP53 (0.58) | TP53CES2CES1ALDH1A1TSHR | |
| SCHEMBL3940663 | 0.81 | TP53 (0.59) | TP53CES2CES1ALDH1A1TSHR | |
| SCHEMBL3940656 | 0.81 | TP53 (0.59) | TP53CES2CES1ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0823420-B1 | Substituted vinylurea derivatives and their use as ACAT inhibitors | SS PHARMACEUTICAL CO (JP) | 2001-10-24 | — | — | EP | disclosed |
| US-5866609-A | PROPHYLACTIC AND THERAPEUTIC AGENTS FOR ARTERIOSCLEROSIS. | SS PHARMACEUTICAL CO., LTD. (JP) | 1999-02-02 | — | — | US | disclosed |
| EP-0823420-A2 | Substituted vinylurea derivatives and their use as ACAT inhibitors | SS PHARMACEUTICAL CO., LTD. (JP) | 1998-02-11 | — | — | EP | disclosed |