Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 3/20 | 0.72 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.70 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.67 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.67 |
| ▸ | HPGD | P15428 | 1/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.67 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | CFD | P00746 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7062641 | 0.86 | PDGFRB (0.72) | FLT3PDGFRBPDGFRACYP1A2CYP2C9 | |
| SCHEMBL7066142 | 0.85 | FLT3 (0.69) | FLT3PDGFRBPDGFRAKDM4ESRD5A2 | |
| SCHEMBL7066092 | 0.84 | FLT3 (0.78) | FLT3PDGFRBPDGFRAKDM4ESRD5A2 | |
| SCHEMBL709521 | 0.83 | FLT3 (0.77) | FLT3PDGFRBPDGFRAKDM4ESRD5A2 | |
| SCHEMBL6870759 | 0.83 | PDGFRB (1.00) | FLT3PDGFRBPDGFRAKDM4ESRD5A2 | |
| SCHEMBL5510398 | 0.82 | PDGFRB (0.73) | FLT3PDGFRBPDGFRAKDM4ESRD5A2 | |
| SCHEMBL7067509 | 0.82 | FLT3 (0.77) | FLT3PDGFRBPDGFRAKDM4ESRD5A2 | |
| SCHEMBL6599162 | 0.82 | KDM4E (0.77) | FLT3PDGFRBPDGFRAKDM4ESRD5A2 | |
| SCHEMBL13133298 | 0.81 | KDM4E (0.81) | FLT3PDGFRBPDGFRAKDM4ESRD5A2 | |
| SCHEMBL630515 | 0.81 | SRD5A2 (1.00) | FLT3PDGFRBPDGFRAKDM4ESRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030158216-A1 | 2-acyl indole derivatives and their use as antitumor agents | BAXTER ONCOLOGY GMBH | 2003-08-21 | — | — | US | disclosed |
| US-20020091124-A1 | 2-acyl indole derivatives and their use as antitumor agents | BECKERS THOMAS (DE) | 2002-07-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030158216-A1 | 2-acyl indole derivatives and their use as antitumor agents | IDO1, IDO2, INMT | FLT3 1953/4885PDGFRB 3807/4885PDGFRA 3147/4885 |
| US-20020091124-A1 | 2-acyl indole derivatives and their use as antitumor agents | IDO1, IDO2, INMT | FLT3 1953/4885PDGFRB 3807/4885PDGFRA 3147/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.