Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4466404 | 0.83 | HTR6 (0.48) | ALDH1A1PSIP1TSHR | |
| SCHEMBL14840376 | 0.82 | ALDH1A1 (0.49) | ALDH1A1CYP1A2GAA | |
| SCHEMBL331215 | 0.77 | KDM4E (0.63) | ALDH1A1CYP1A2PSIP1KEAP1 | |
| SCHEMBL21297026 | 0.77 | NR1I2 (0.49) | ALDH1A1CYP1A2CYP2C9CYP2C19PSIP1 | |
| SCHEMBL578793 | 0.76 | HTR6 (0.55) | ALDH1A1PSIP1KEAP1TSHR | |
| SCHEMBL20533805 | 0.76 | HTR6 (0.55) | ALDH1A1PSIP1KEAP1TSHR | |
| SCHEMBL3178375 | 0.76 | HTR6 (0.55) | ALDH1A1PSIP1KEAP1TSHR | |
| SCHEMBL20583771 | 0.76 | HTR6 (0.55) | ALDH1A1CYP2C9CYP2C19PSIP1KEAP1 | |
| Lithium Ion SCHEMBL1457873 | 0.76 | HTR6 (0.55) | ALDH1A1PSIP1KEAP1TSHR | |
| SCHEMBL284565 | 0.76 | HTR6 (0.55) | ALDH1A1PSIP1KEAP1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1349894-A2 | POLYCARBONATE-POLYESTER COMPOSITIONS WITH ENHANCED FLOW | GENERAL ELECTRIC COMPANY (US) | 2003-10-08 | — | — | EP | disclosed |
| US-6599966-B2 | Containing phosphonium sulfonate additive | GENERAL ELECTRIC COMPANY | 2003-07-29 | — | — | US | disclosed |
| US-6583256-B2 | Comprising a resorcinol-isophthalic or terephthalic acid-co-bisphenol a polycarbonate block copolymer, a polyalkylene dicarboxylate, and at least one impact modifier; nonyellowing; articles such as car, truck, motorcycle panels | GENERAL ELECTRIC COMPANY | 2003-06-24 | — | — | US | disclosed |
| US-20020132889-A1 | Polycarbonate-polyester compositions with enhanced flow | SABIC INNOVATIVE PLASTICS IP B.V. (NL) | 2002-09-19 | — | — | US | disclosed |
| WO-2002048263-A2 | POLYCARBONATE-POLYESTER COMPOSITIONS WITH ENHANCED FLOW | GENERAL ELECTRIC COMPANY (US) | 2002-06-20 | — | — | WO | disclosed |
| US-20010016626-A1 | Weatherable block copolyestercarbonate compositions | SABIC GLOBAL TECHNOLOGIES B.V. (NL) | 2001-08-23 | — | — | US | disclosed |