Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 3/20 | 0.32 |
| ▸ | MMP9 | P14780 | 3/20 | 0.32 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.31 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.31 |
| ▸ | MMP8 | P22894 | 2/20 | 0.31 |
| ▸ | MMP13 | P45452 | 2/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29042467 | 0.80 | KDM4E (0.33) | KDM4EPKMMMP2MMP9MMP3 | |
| SCHEMBL21385037 | 0.77 | KDM4E (0.31) | KDM4EPKMMMP2MMP9MMP3 | |
| SCHEMBL2161308 | 0.76 | KDM4E (0.35) | KDM4EPKMOPRM1OPRL1 | |
| SCHEMBL9848988 | 0.76 | CES2 (0.33) | KDM4EPKMOPRK1USP2MEN1 | |
| SCHEMBL13425231 | 0.75 | KDM4E (0.33) | KDM4EPKMCYP2C19KMT2A | |
| SCHEMBL10581338 | 0.73 | KDM4E (0.34) | KDM4EPKM | |
| SCHEMBL5838603 | 0.73 | KDM4E (0.31) | KDM4EPKM | |
| SCHEMBL6057108 | 0.71 | KDM4E (0.38) | KDM4EPKMMMP2MMP9MMP3 | |
| SCHEMBL11521532 | 0.71 | MAOB (0.37) | SIGMAR1NPSR1L3MBTL1 | |
| SCHEMBL6760414 | 0.70 | KDM4E (0.37) | KDM4EPKMMMP2MMP9MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004087061-A2 | TUBULIN BINDING AGENTS AND CORRESPONDING PRODRUG CONSTRUCTS | OXIGENE, INC. (US) | 2004-10-14 | — | — | WO | disclosed |