Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 8/20 | 0.43 |
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | RBM39 | Q14498 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7064608 | 0.85 | MAPT (0.44) | ERN1MAPTALDH1A1LMNAMEN1 | |
| SCHEMBL7066486 | 0.85 | ALDH1A1 (0.44) | MAPTALDH1A1LMNAMEN1HTT | |
| SCHEMBL7065379 | 0.85 | MAPT (0.42) | ERN1MAPTALDH1A1LMNAMEN1 | |
| SCHEMBL7065861 | 0.84 | MAPT (0.53) | MAPTALDH1A1MEN1HTTKMT2A | |
| SCHEMBL7064483 | 0.83 | ERN1 (0.43) | ERN1MAPTALDH1A1LMNAMEN1 | |
| SCHEMBL7064489 | 0.83 | ERN1 (0.43) | ERN1MAPTALDH1A1LMNAMEN1 | |
| SCHEMBL915958 | 0.83 | ALDH1A1 (0.44) | MAPTALDH1A1LMNAMEN1HTT | |
| SCHEMBL7064644 | 0.81 | MAPT (0.44) | MAPTALDH1A1LMNAMEN1HTT | |
| SCHEMBL7062299 | 0.80 | GFER (0.48) | MAPTALDH1A1LMNAMEN1HTT | |
| SCHEMBL7060004 | 0.80 | GFER (0.42) | MAPTALDH1A1LMNAMEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1313461-A2 | THE USE OF BENZYLIDENEAMINOGUANIDINES AND HYDROXYGUANIDINES AS MELANOCORTIN RECEPTOR LIGANDS | Melacure Therapeutics AB (SE) | 2003-05-28 | — | — | EP | disclosed |
| WO-2002011715-A2 | THE USE OF BENZYLIDENEAMINOGUANIDINES AND HYDROXYGUANIDINES AS MELANOCORTIN RECEPTOR LIGANDS | MELACURE THERAPEUTICS AB (SE) | 2002-02-14 | — | — | WO | disclosed |