Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SDCBP | O00560 | 7/20 | 0.47 |
| ▸ | SDC2 | P34741 | 7/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7064833 | 1.00 | SDCBP (0.47) | SDCBPSDC2ALDH1A1POLBKDM4E | |
| SCHEMBL8037876 | 0.89 | ALDH1A1 (0.44) | ALDH1A1POLBKDM4ETP53GLA | |
| SCHEMBL7063363 | 0.89 | ALDH1A1 (0.44) | ALDH1A1POLBKDM4ETP53GLA | |
| SCHEMBL7063368 | 0.89 | ALDH1A1 (0.44) | ALDH1A1POLBKDM4ETP53GLA | |
| SCHEMBL7063991 | 0.86 | SDCBP (0.49) | SDCBPSDC2ALDH1A1POLBKDM4E | |
| SCHEMBL7063999 | 0.86 | SDCBP (0.49) | SDCBPSDC2ALDH1A1POLBKDM4E | |
| SCHEMBL7349201 | 0.84 | ALDH1A1 (0.64) | ALDH1A1POLBKDM4ETP53GLA | |
| SCHEMBL7349189 | 0.84 | ALDH1A1 (0.64) | ALDH1A1POLBKDM4ETP53GLA | |
| SCHEMBL8090711 | 0.83 | ALDH1A1 (0.53) | ALDH1A1POLBKDM4ETP53GLA | |
| SCHEMBL8090704 | 0.83 | ALDH1A1 (0.53) | ALDH1A1POLBKDM4ETP53GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0728746-B1 | Azepinone compounds useful in the inhibition of ACE and NEP | BRISTOL MYERS SQUIBB CO (US) | 2003-05-28 | — | — | EP | disclosed |
| US-6143886-A | CYCLOPROPYL-SUBSTITUTED AZEPINONE COMPOUNDS WHICH ARE USEFUL EITHER AS SELECTIVE ANGIOTENSIN CONVERTING ENZYME INHIBITORS, OR AS DUAL INHIBITORS OF BOTH ANGIOTENSIN CONVERTING ENZYME AND NEUTRAL ENDOPEPTIDASE | BRISTOL-MYERS SQUIBB CO. (US) | 2000-11-07 | — | — | US | disclosed |
| US-5994537-A | Process for preparing azepinone compounds useful in the inhibition of ACE and NEP | BRISTOL-MYERS SQUIBB CO. (US) | 1999-11-30 | — | — | US | disclosed |
| US-5587375-A | TREATING BLOOD PRESSURE, INTRAOCULAR PRESSURE, CARDIOVASCULAR DISORDERS, GLAUCOMA, AND RENAL DISEASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-12-24 | — | — | US | disclosed |
| EP-0728746-A1 | Azepinone compounds useful in the inhibition of ACE and NEP | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-08-28 | — | — | EP | disclosed |