Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 16/20 | 0.49 |
| ▸ | KDR | P35968 | 12/20 | 0.49 |
| ▸ | MAP2K1 | Q02750 | 4/20 | 0.48 |
| ▸ | RAF1 | P04049 | 2/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | BCR | P11274 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | YES1 | P07947 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | CSK | P41240 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7068675 | 0.99 | SRC (0.49) | SRCKDRMAP2K1RAF1ABL1 | |
| Hydrochloric Acid SCHEMBL7130370 | 0.85 | SRC (0.68) | SRCKDRMAP2K1RAF1ABL1 | |
| SCHEMBL7068322 | 0.83 | SRC (0.49) | SRCKDRMAP2K1RAF1ABL1 | |
| Hydrochloric Acid SCHEMBL7067904 | 0.82 | SRC (0.48) | SRCKDRMAP2K1RAF1ABL1 | |
| SCHEMBL7069410 | 0.81 | SRC (0.54) | SRCKDRMAP2K1ABL1BCR | |
| SCHEMBL7068171 | 0.81 | SRC (0.53) | SRCKDRMAP2K1ABL1BCR | |
| SCHEMBL5461933 | 0.79 | SRC (0.53) | SRCKDRMAP2K1RAF1EGFR | |
| SCHEMBL5455231 | 0.79 | SRC (0.56) | SRCKDRMAP2K1RAF1ABL1 | |
| SCHEMBL5459201 | 0.79 | SRC (0.51) | SRCKDRMAP2K1ABL1BCR | |
| SCHEMBL7066587 | 0.79 | SRC (0.71) | SRCKDRMAP2K1RAF1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003047583-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING BENZOFURANYL SUBSTITUTED 3-CYANOQUINOLINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF SOLID TUMOURS | ASTRAZENECA AB (SE) | 2003-06-12 | — | — | WO | claimed |