Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 13/20 | 0.49 |
| ▸ | KDR | P35968 | 3/20 | 0.49 |
| ▸ | ABL1 | P00519 | 7/20 | 0.48 |
| ▸ | ABL2 | P42684 | 7/20 | 0.48 |
| ▸ | EGFR | P00533 | 5/20 | 0.45 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.45 |
| ▸ | FLT1 | P17948 | 1/20 | 0.44 |
| ▸ | RAF1 | P04049 | 1/20 | 0.44 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.44 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.40 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7067904 | 0.99 | SRC (0.48) | SRCKDRABL1ABL2EGFR | |
| SCHEMBL7065293 | 0.89 | SRC (0.46) | SRCABL1ABL2EGFRERBB2 | |
| Hydrochloric Acid SCHEMBL7070735 | 0.88 | SRC (0.45) | SRCABL1ABL2EGFRERBB2 | |
| SCHEMBL7068505 | 0.87 | SRC (0.50) | SRCKDRABL1ABL2EGFR | |
| SCHEMBL7068176 | 0.83 | SRC (0.52) | SRCKDRABL1ABL2EGFR | |
| Hydrochloric Acid SCHEMBL7066964 | 0.83 | SRC (0.70) | SRCKDRABL1ABL2EGFR | |
| SCHEMBL7065518 | 0.83 | SRC (0.49) | SRCKDRABL1EGFRRAF1 | |
| Hydrochloric Acid SCHEMBL7068675 | 0.82 | SRC (0.49) | SRCKDRABL1EGFRRAF1 | |
| Hydrochloric Acid SCHEMBL3279304 | 0.82 | SRC (0.69) | SRCKDREGFRERBB2 | |
| SCHEMBL5471839 | 0.78 | SRC (0.51) | SRCKDRABL1ABL2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003047583-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING BENZOFURANYL SUBSTITUTED 3-CYANOQUINOLINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF SOLID TUMOURS | ASTRAZENECA AB (SE) | 2003-06-12 | — | — | WO | disclosed |
| WO-2003048159-A1 | QUINOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2003-06-12 | — | — | WO | disclosed |