Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 16/20 | 0.52 |
| ▸ | ABL1 | P00519 | 10/20 | 0.52 |
| ▸ | ABL2 | P42684 | 10/20 | 0.52 |
| ▸ | EGFR | P00533 | 2/20 | 0.46 |
| ▸ | KDR | P35968 | 3/20 | 0.45 |
| ▸ | FLT1 | P17948 | 1/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.44 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7067557 | 0.88 | SRC (0.50) | SRCABL1ABL2EGFRKDR | |
| SCHEMBL7068724 | 0.85 | SRC (0.51) | SRCABL1ABL2EGFRKDR | |
| SCHEMBL7068171 | 0.85 | SRC (0.53) | SRCABL1ABL2EGFRKDR | |
| SCHEMBL7068322 | 0.83 | SRC (0.49) | SRCABL1ABL2EGFRKDR | |
| SCHEMBL7065783 | 0.83 | SRC (0.48) | SRCABL1ABL2EGFRKDR | |
| SCHEMBL7068505 | 0.82 | SRC (0.50) | SRCABL1ABL2EGFRKDR | |
| Hydrochloric Acid SCHEMBL7067904 | 0.82 | SRC (0.48) | SRCABL1ABL2EGFRKDR | |
| Hydrochloric Acid SCHEMBL7066964 | 0.78 | SRC (0.70) | SRCABL1ABL2EGFRKDR | |
| SCHEMBL3673893 | 0.78 | SRC (0.72) | SRCABL1ABL2EGFRKDR | |
| SCHEMBL3673891 | 0.78 | SRC (0.54) | SRCABL1ABL2EGFRKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003047584-A1 | QUINOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2003-06-12 | — | — | WO | disclosed |
| WO-2003047585-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING BENZOFURANYL SUBSTITUTED 3-CYANOQUINOLINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF SOLID TUMOURS | ASTRAZENECA AB (SE) | 2003-06-12 | — | — | WO | disclosed |