Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 18/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7066266 | 1.00 | MMP1 (0.66) | MMP1CYP2D6MAPT | |
| SCHEMBL7985753 | 0.88 | MMP1 (0.70) | MMP1CYP2D6MAPT | |
| SCHEMBL7362840 | 0.88 | MMP1 (0.70) | MMP1CYP2D6MAPT | |
| SCHEMBL7064618 | 0.88 | MMP1 (0.70) | MMP1CYP2D6MAPT | |
| SCHEMBL7067996 | 0.87 | MMP1 (0.85) | MMP1 | |
| SCHEMBL7064556 | 0.87 | MMP1 (0.85) | MMP1 | |
| SCHEMBL7064583 | 0.87 | MMP1 (0.64) | MMP1CYP2D6MAPT | |
| SCHEMBL7066925 | 0.87 | MMP1 (0.64) | MMP1CYP2D6MAPT | |
| SCHEMBL7064579 | 0.87 | MMP1 (0.64) | MMP1CYP2D6MAPT | |
| SCHEMBL7063369 | 0.86 | MMP1 (0.65) | MMP1CYP2D6MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0966439-B1 | CERTAIN CYCLIC THIO SUBSTITUTED ACYLAMINOACID AMIDE DERIVATIVES | NOVARTIS AG (CH) | 2003-06-04 | — | — | EP | disclosed |
| US-6201133-B1 | FOR INHIBITING MATRIX-DEGRADING METALLOPROTEINASES IN MAMMALS, TREATING TNF ALPHA AND MATRIX METALLOPROTEINASE DEPENDENT DISEASES OR CONDITIONS, CANCER | NOVARTIS AG (CH) | 2001-03-13 | — | — | US | disclosed |
| US-6034136-A | METALLOPROTEINASE INHIBITOR | NOVARTIS AG (CH) | 2000-03-07 | — | — | US | disclosed |
| EP-0966439-A1 | CERTAIN CYCLIC THIO SUBSTITUTED ACYLAMINOACID AMIDE DERIVATIVES | Novartis AG (CH) | 1999-12-29 | — | — | EP | disclosed |
| WO-1998042662-A1 | CERTAIN CYCLIC THIO SUBSTITUTED ACYLAMINOACID AMIDE DERIVATIVES | NOVARTIS AG (CH) | 1998-10-01 | — | — | WO | disclosed |