Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7066166 | 0.98 | SIGMAR1 (0.33) | SIGMAR1HTR6HTR2A | |
| Hydrochloric Acid SCHEMBL7066628 | 0.97 | SIGMAR1 (0.33) | SIGMAR1HTR6HTR2A | |
| SCHEMBL7061981 | 0.96 | SIGMAR1 (0.34) | SIGMAR1HTR6HTR2A | |
| Bromide SCHEMBL7064187 | 0.95 | SIGMAR1 (0.33) | SIGMAR1HTR6HTR2A | |
| Hydrochloric Acid SCHEMBL7065674 | 0.95 | SIGMAR1 (0.33) | SIGMAR1HTR6HTR2A | |
| Methyl Alcohol SCHEMBL7062086 | 0.93 | SIGMAR1 (0.33) | SIGMAR1HTR6HTR2A | |
| Bromide SCHEMBL7065912 | 0.93 | SIGMAR1 (0.33) | SIGMAR1HTR6HTR2A | |
| Methyl Alcohol SCHEMBL7062236 | 0.92 | SIGMAR1 (0.32) | SIGMAR1HTR6HTR2A | |
| SCHEMBL6831898 | 0.79 | SIGMAR1 (0.33) | SIGMAR1HTR6HTR2A | |
| Hydrochloric Acid SCHEMBL7766826 | 0.79 | HTR2A (0.33) | SIGMAR1HTR6HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0530908-B2 | Process for the preparation of a bridged metallocene compound as well as a catalyst component and a process for the polymerization of olefins | DSM NV (NL) | 2003-06-04 | — | — | EP | disclosed |
| EP-0530908-B1 | Process for the preparation of a bridged metallocene compound as well as a catalyst component and a process for the polymerization of olefins | DSM NV (NL) | 1999-04-21 | — | — | EP | disclosed |
| US-5646083-A | Process for the preparation of a bridged metallocene compound as well as a catalyst component and a process for the polymerization of olefins | DSM N.V. (NL) | 1997-07-08 | — | — | US | disclosed |
| EP-0530908-A1 | Process for the preparation of a bridged metallocene compound as well as a catalyst component and a process for the polymerization of olefins | DSM N.V. (NL) | 1993-03-10 | — | — | EP | disclosed |