Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 4/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
| ▸ | MGLL | Q99685 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.31 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.31 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7066653 | 1.00 | GABRA1 (0.36) | GABRA1GABRB2MAPTNPSR1L3MBTL1 | |
| SCHEMBL1992791 | 0.76 | CES2 (0.37) | MAPTCYP3A4OPRM1 | |
| SCHEMBL1996851 | 0.76 | NISCH (0.49) | MAPTL3MBTL1NISCHCYP3A4CYP2D6 | |
| SCHEMBL1996852 | 0.76 | NISCH (0.49) | MAPTL3MBTL1NISCHCYP3A4CYP2D6 | |
| SCHEMBL1992790 | 0.76 | CES2 (0.37) | MAPTCYP3A4OPRM1 | |
| SCHEMBL1994396 | 0.76 | CES2 (0.37) | MAPTCYP3A4OPRM1 | |
| SCHEMBL910689 | 0.75 | GABRA1 (0.39) | GABRA1GABRB2MAPTNPSR1L3MBTL1 | |
| SCHEMBL1992582 | 0.73 | CYP1A2 (0.46) | CYP2D6ADRA2AADRA2BADRA2C | |
| SCHEMBL1999803 | 0.71 | ACP3 (0.41) | CYP3A4SLC6A4ADRA2AADRA2BADRA2C | |
| SCHEMBL14650862 | 0.71 | GABRA1 (0.41) | GABRA1GABRB2MAPTNPSR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0920325-A3 | TETRAPEPTIDE DERIVATIVES OF DOLASTATIN AS ANTITUMOR AGENTS | BASF AKTIENGESELLSCHAFT (DE) | 2003-06-04 | — | — | EP | claimed |
| EP-0920325-A2 | TETRAPEPTIDE DERIVATIVES OF DOLASTATIN AS ANTITUMOR AGENTS | BASF AKTIENGESELLSCHAFT (DE) | 1999-06-09 | — | — | EP | claimed |
| WO-1998004278-A2 | TETRAPEPTIDE DERIVATIVES OF DOLASTATIN AS ANTITUMOR AGENTS | BASF AKTIENGESELLSCHAFT (DE) | 1998-02-05 | — | — | WO | claimed |
| EP-0920325-A3 | TETRAPEPTIDE DERIVATIVES OF DOLASTATIN AS ANTITUMOR AGENTS | BASF AKTIENGESELLSCHAFT (DE) | 2003-06-04 | — | — | EP | disclosed |
| US-5939527-A | SYNTHETIC OLIGOPEPTIDE WITH BIOLOGICAL ACTIVITY OF DOLASTATIN FROM SEA HARE | BASF AKTIENGESELLSCHAFT (DE) | 1999-08-17 | — | — | US | disclosed |
| US-5939527-A | SYNTHETIC OLIGOPEPTIDE WITH BIOLOGICAL ACTIVITY OF DOLASTATIN FROM SEA HARE | BASF AKTIENGESELLSCHAFT (DE) | 1999-08-17 | — | — | US | disclosed |
| EP-0920325-A2 | TETRAPEPTIDE DERIVATIVES OF DOLASTATIN AS ANTITUMOR AGENTS | BASF AKTIENGESELLSCHAFT (DE) | 1999-06-09 | — | — | EP | disclosed |
| WO-1998004278-A2 | TETRAPEPTIDE DERIVATIVES OF DOLASTATIN AS ANTITUMOR AGENTS | BASF AKTIENGESELLSCHAFT (DE) | 1998-02-05 | — | — | WO | disclosed |