Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.37 |
| ▸ | SSTR2 | P30874 | 5/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 3/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | SSTR4 | P31391 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5465843 | 0.77 | AAK1 (0.35) | SSTR2EGFRERBB2SSTR4CYP2C9 | |
| SCHEMBL1344423 | 0.73 | LRRK2 (0.54) | LRRK2EGFRERBB2RAF1MAP2K1 | |
| SCHEMBL29354716 | 0.71 | LRRK2 (0.43) | LRRK2EGFRRAF1MAP2K1SRC | |
| SCHEMBL28207054 | 0.71 | KDM4E (0.37) | PARP1LRRK2 | |
| SCHEMBL6643350 | 0.70 | KCNMA1 (0.41) | PARP1LRRK2EGFRERBB2 | |
| SCHEMBL30818296 | 0.70 | KCNMA1 (0.41) | PARP1LRRK2EGFRERBB2 | |
| SCHEMBL23803683 | 0.70 | EGFR (0.36) | SLC6A3EGFRERBB2MAP2K1SRC | |
| SCHEMBL30673280 | 0.69 | ALB (0.42) | BCAT1 | |
| SCHEMBL505592 | 0.69 | ALB (0.42) | BCAT1 | |
| SCHEMBL6643099 | 0.69 | CYP11B2 (0.36) | SSTR2LRRK2EGFRERBB2MAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003047583-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING BENZOFURANYL SUBSTITUTED 3-CYANOQUINOLINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF SOLID TUMOURS | ASTRAZENECA AB (SE) | 2003-06-12 | — | — | WO | disclosed |
| WO-2003047582-A1 | QUINOLINE DERIVATIVES AS ANTITUMOUR AGENTS | ASTRAZENECA AB (SE) | 2003-06-12 | — | — | WO | disclosed |
| WO-2003048159-A1 | QUINOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2003-06-12 | — | — | WO | disclosed |