Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 3/20 | 0.42 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.39 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.36 |
| ▸ | ACLY | P53396 | 2/20 | 0.36 |
| ▸ | IDH1 | O75874 | 1/20 | 0.35 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.33 |
| ▸ | ESRRA | P11474 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | BRD1 | O95696 | 1/20 | 0.33 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7069156 | 0.80 | CXCR2 (0.56) | CXCR2CXCR1MAPTKDM4EALDH1A1 | |
| SCHEMBL7067490 | 0.79 | CXCR2 (0.48) | ARCXCR2CXCR1LRRK2EGFR | |
| SCHEMBL6129921 | 0.73 | CXCR2 (0.47) | ARCXCR2CXCR1LRRK2EGFR | |
| SCHEMBL22954626 | 0.71 | LRRK2 (0.54) | ARLRRK2ACLYIDH1TRIM24 | |
| SCHEMBL30376409 | 0.70 | AR (0.51) | ARMAPTSLC6A4EGLN2ESRRA | |
| SCHEMBL364484 | 0.70 | AR (0.51) | ARMAPTSLC6A4EGLN2ESRRA | |
| SCHEMBL6930935 | 0.69 | AR (0.37) | ARCXCR2CXCR1LRRK2EGFR | |
| SCHEMBL30118209 | 0.67 | AR (0.51) | ARSLC6A4EGLN2ESRRAKDM4E | |
| SCHEMBL708391 | 0.67 | AR (0.51) | ARSLC6A4EGLN2ESRRAKDM4E | |
| SCHEMBL15507439 | 0.67 | HTT (0.48) | ARLRRK2ACLYIDH1TRIM24 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1265905-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2003-03-12 | — | — | EP | disclosed |
| EP-1265905-A1 | IL-8 RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2002-12-18 | — | — | EP | disclosed |
| WO-2001064691-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-09-07 | — | — | WO | disclosed |