Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 3/20 | 0.37 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.37 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.37 |
| ▸ | STK10 | O94804 | 3/20 | 0.34 |
| ▸ | SLK | Q9H2G2 | 3/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | ACLY | P53396 | 2/20 | 0.34 |
| ▸ | IDH1 | O75874 | 1/20 | 0.33 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | CLK2 | P49760 | 1/20 | 0.32 |
| ▸ | GSK3A | P49840 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.32 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6930932 | 0.92 | CXCR2 (0.38) | ARCXCR2CXCR1LRRK2ACLY | |
| SCHEMBL6931040 | 0.81 | CXCR2 (0.34) | ARCXCR2CXCR1LRRK2ACLY | |
| SCHEMBL6931039 | 0.80 | CXCR2 (0.38) | ARCXCR2CXCR1LRRK2IDH1 | |
| SCHEMBL7097896 | 0.79 | CXCR2 (0.45) | CXCR2CXCR1 | |
| SCHEMBL7067490 | 0.72 | CXCR2 (0.48) | ARCXCR2CXCR1LRRK2ACLY | |
| SCHEMBL6129921 | 0.70 | CXCR2 (0.47) | ARCXCR2CXCR1LRRK2ACLY | |
| SCHEMBL7067489 | 0.69 | AR (0.42) | ARCXCR2CXCR1LRRK2ACLY | |
| SCHEMBL6930049 | 0.67 | CXCR2 (0.48) | CXCR2CXCR1 | |
| SCHEMBL22954626 | 0.65 | LRRK2 (0.54) | ARLRRK2ACLYIDH1MAPT | |
| SCHEMBL30376409 | 0.65 | AR (0.51) | ARMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1265905-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2003-03-12 | — | — | EP | disclosed |
| US-20030028042-A1 | Il8-receptor antagonists | SMITHKLINE BEECHAM CORPORATION | 2003-02-06 | — | — | US | disclosed |
| EP-1265905-A1 | IL-8 RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2002-12-18 | — | — | EP | disclosed |
| WO-2001064691-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-09-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030028042-A1 | Il8-receptor antagonists | CXCL8, CCR8, IL1RN | AR 1177/4885CXCR2 28/4885CXCR1 37/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.