Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 13/20 | 0.77 |
| ▸ | ADORA3 | P0DMS8 | 8/20 | 0.77 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.77 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.67 |
| ▸ | SLC29A1 | Q99808 | 2/20 | 0.67 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.67 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.64 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.64 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7067588 | 1.00 | ADORA1 (0.77) | ADORA1ADORA3ADORA2AADORA2BSLC29A1 | |
| SCHEMBL7067551 | 0.95 | ADORA1 (0.76) | ADORA1ADORA3ADORA2AADORA2BSLC29A1 | |
| SCHEMBL7066024 | 0.95 | ADORA1 (0.76) | ADORA1ADORA3ADORA2AADORA2BSLC29A1 | |
| SCHEMBL7064261 | 0.90 | ADORA2A (0.68) | ADORA1ADORA3ADORA2AADORA2BSLC29A1 | |
| SCHEMBL7067118 | 0.90 | ADORA1 (0.74) | ADORA1ADORA3ADORA2AADORA2BSLC29A1 | |
| SCHEMBL7067115 | 0.90 | ADORA1 (0.74) | ADORA1ADORA3ADORA2AADORA2BSLC29A1 | |
| SCHEMBL6660596 | 0.88 | ADORA3 (0.86) | ADORA1ADORA3ADORA2AADORA2BSLC29A1 | |
| SCHEMBL6660602 | 0.88 | ADORA3 (0.86) | ADORA1ADORA3ADORA2AADORA2BSLC29A1 | |
| SCHEMBL7067811 | 0.87 | ADORA1 (0.58) | ADORA1ADORA3ADORA2AADORA2B | |
| SCHEMBL7067807 | 0.87 | ADORA1 (0.58) | ADORA1ADORA3ADORA2AADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1027363-B1 | ADENOSINE A1-RECEPTOR AGONISTS | GLAXO GROUP LTD (GB) | 2003-06-04 | — | — | EP | claimed |
| EP-1027363-A2 | ADENOSINE A1-RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 2000-08-16 | — | — | EP | claimed |
| WO-1999024450-A2 | ADENSINE A1 RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 1999-05-20 | — | — | WO | claimed |
| US-6407076-B1 | ANTIISCHEMIC, ANTILIPOLYTIC, ANTICONVULSANT AND HYPOTENSIVE AGENTS; CARDIOVASCULAR AND NERVOUS SYSTEM DISORDERS; ATHEROSCLEROSIS | SMITHKLINE BEECHAM CORPORATION | 2002-06-18 | — | — | US | disclosed |