Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 5/20 | 0.68 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.68 |
| ▸ | ADORA3 | P0DMS8 | 6/20 | 0.66 |
| ▸ | TSHR | P16473 | 3/20 | 0.62 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.62 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.62 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.62 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.62 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.62 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.62 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7067588 | 0.90 | ADORA1 (0.77) | ADORA2AADORA1ADORA3PMP22ADORA2B | |
| SCHEMBL7067593 | 0.90 | ADORA1 (0.77) | ADORA2AADORA1ADORA3PMP22ADORA2B | |
| SCHEMBL6660699 | 0.88 | ADORA3 (0.84) | ADORA2AADORA1ADORA3TSHRPMP22 | |
| SCHEMBL6253593 | 0.87 | ADORA2A (0.80) | ADORA2AADORA1ADORA3TSHRPMP22 | |
| SCHEMBL7066024 | 0.87 | ADORA1 (0.76) | ADORA2AADORA1ADORA3ADORA2BSLC29A1 | |
| SCHEMBL7067551 | 0.87 | ADORA1 (0.76) | ADORA2AADORA1ADORA3ADORA2BSLC29A1 | |
| SCHEMBL7064488 | 0.84 | ADORA3 (0.65) | ADORA2AADORA1ADORA3ADORA2BTAS1R3 | |
| SCHEMBL7067829 | 0.82 | ADORA1 (0.78) | ADORA2AADORA1ADORA3PMP22ADORA2B | |
| SCHEMBL7067836 | 0.82 | ADORA1 (0.78) | ADORA2AADORA1ADORA3PMP22ADORA2B | |
| SCHEMBL7067579 | 0.82 | ADORA3 (0.61) | ADORA2AADORA1ADORA3ADORA2BTAS1R3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1027363-B1 | ADENOSINE A1-RECEPTOR AGONISTS | GLAXO GROUP LTD (GB) | 2003-06-04 | — | — | EP | claimed |
| EP-1027363-A2 | ADENOSINE A1-RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 2000-08-16 | — | — | EP | claimed |
| WO-1999024450-A2 | ADENSINE A1 RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 1999-05-20 | — | — | WO | claimed |
| US-6407076-B1 | ANTIISCHEMIC, ANTILIPOLYTIC, ANTICONVULSANT AND HYPOTENSIVE AGENTS; CARDIOVASCULAR AND NERVOUS SYSTEM DISORDERS; ATHEROSCLEROSIS | SMITHKLINE BEECHAM CORPORATION | 2002-06-18 | — | — | US | disclosed |
| EP-1027363-A2 | ADENOSINE A1-RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 2000-08-16 | — | — | EP | disclosed |
| WO-1999024450-A2 | ADENSINE A1 RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 1999-05-20 | — | — | WO | disclosed |