Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 2/20 | 0.50 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.50 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 2/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | CLK1 | P49759 | 2/20 | 0.46 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.46 |
| ▸ | CLK2 | P49760 | 2/20 | 0.46 |
| ▸ | GSK3B | P49841 | 2/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.46 |
| ▸ | CLK3 | P49761 | 1/20 | 0.46 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.46 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31460000 | 1.00 | PIM1 (0.50) | PIM1PIM3PIM2FGFR1NPC1 | |
| Hydrochloric Acid SCHEMBL11207451 | 0.98 | PIM1 (0.49) | PIM1PIM3PIM2FGFR1NPC1 | |
| SCHEMBL23884385 | 0.93 | HSP90AA1 (0.47) | PIM1PIM3PIM2FGFR1NPC1 | |
| SCHEMBL842550 | 0.79 | CHEK1 (0.52) | PIM1PIM3PIM2FGFR1RAB9A | |
| SCHEMBL150476 | 0.78 | NPC1 (0.65) | NPC1POLBRAB9AHSP90AA1DYRK1A | |
| SCHEMBL29350099 | 0.78 | NPC1 (0.65) | NPC1POLBRAB9AHSP90AA1DYRK1A | |
| SCHEMBL1572257 | 0.77 | HSP90AA1 (0.64) | FGFR1RAB9ACDK2HSP90AA1IDO1 | |
| SCHEMBL29680194 | 0.77 | HSP90AA1 (0.64) | FGFR1RAB9ACDK2HSP90AA1IDO1 | |
| Quinoline SCHEMBL9383866 | 0.75 | HSP90AA1 (0.68) | PIM1PIM3PIM2FGFR1NPC1 | |
| SCHEMBL13156520 | 0.74 | NPC1 (0.60) | NPC1POLBRAB9AHSP90AA1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0250179-A2 | BCD tricyclic ergoline part-structure analogues | ELI LILLY AND COMPANY (US) | 1987-12-23 | — | — | EP | claimed |
| US-20030212085-A1 | Treatment of fibromyalgia and chronic fatigue syndrome | PHARMACIA & UPJOHN COMPANY | 2003-11-13 | — | — | US | disclosed |
| EP-1280530-A1 | TREATMENT OF FIBROMYALGIA AND CHRONIC FATIGUE SYNDROME | PHARMACIA & UPJOHN COMPANY (US) | 2003-02-05 | — | — | EP | disclosed |
| WO-2002083141-A1 | TREATMENT OF FIBROMYALGIA AND CHRONIC FATIGUE SYNDROME | PHARMACIA & UPJOHN COMPANY (US) | 2002-10-24 | — | — | WO | disclosed |
| WO-2001087308-A1 | TREATMENT OF FIBROMYALGIA AND CHRONIC FATIGUE SYNDROME | PHARMACIA & UPJOHN COMPANY (US) | 2001-11-22 | — | — | WO | disclosed |
| US-5169742-A | Development free of benzyl alcohol; addition polymer with sulfinic acid group as stabilizer; color mixing inhibitor; image quality | FUJI PHOTO FILM CO., LTD. (JP) | 1992-12-08 | — | — | US | disclosed |
| US-5134143-A | Dopamine Agonists | ELI LILLY AND COMPANY (US) | 1992-07-28 | — | — | US | disclosed |
| US-5134143-A | Dopamine Agonists | ELI LILLY AND COMPANY (US) | 1992-07-28 | — | — | US | disclosed |
| CN-1016872-B | BCD TRICYCLIC ERGOLINE PART-STRUCTURE ANALOGUSE | LILLY CO ELI (US) | 1992-06-03 | — | — | CN | disclosed |
| EP-0172697-B1 | Octahydro-oxazolo[4,5-g]quinolines | ELI LILLY AND COMPANY (US) | 1991-09-25 | — | — | EP | disclosed |
| EP-0111990-A1 | Hypotensive agents | ELI LILLY AND COMPANY (US) | 1984-06-27 | — | — | EP | disclosed |
| EP-0110496-A2 | Improvements in keto intermediates, their use and preparation | ELI LILLY AND COMPANY (US) | 1984-06-13 | — | — | EP | disclosed |
| EP-0013787-B1 | OCTAHYDRO PYRAZOLO (3,4-G)QUINOLINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ELI LILLY AND COMPANY (US) | 1984-05-02 | — | — | EP | disclosed |
| EP-0050881-B1 | OCTAHYDRO QUINOLINE DERIVATIVES | ELI LILLY AND COMPANY (US) | 1984-04-25 | — | — | EP | disclosed |
| US-4367231-A | PARKINSON*S SYNDROME | ELI LILLY AND COMPANY (US) | 1983-01-04 | — | — | US | disclosed |
| US-4367231-A | PARKINSON*S SYNDROME | ELI LILLY AND COMPANY (US) | 1983-01-04 | — | — | US | disclosed |
| US-4230861-A | DOPAMINE ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1980-10-28 | — | — | US | disclosed |
| EP-0013787-A1 | Octahydro pyrazolo (3,4-g)quinolines, process for their preparation and pharmaceutical compositions containing them | ELI LILLY AND COMPANY (US) | 1980-08-06 | — | — | EP | disclosed |
| US-4198415-A | Prolactin inhibiting octahydro pyrazolo[3,4-g]quinolines | ELI LILLY AND COMPANY (US) | 1980-04-15 | — | — | US | disclosed |
| US-4198415-A | Prolactin inhibiting octahydro pyrazolo[3,4-g]quinolines | ELI LILLY AND COMPANY (US) | 1980-04-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030212085-A1 | Treatment of fibromyalgia and chronic fatigue syndrome | HTR5A, OPRL1, OPRD1 | PIM1 4766/4885PIM3 4536/4885PIM2 4781/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.