Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.47 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.47 |
| ▸ | TRPM8 | Q7Z2W7 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | SNCA | P37840 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7069204 | 1.00 | APP (0.51) | APPMAPTL3MBTL1SRD5A2NPC1 | |
| SCHEMBL7720762 | 0.87 | RAB9A (0.54) | MAPTL3MBTL1NPC1CYP26A1CYP26B1 | |
| SCHEMBL7721861 | 0.86 | TNFRSF1A (0.49) | MAPTCYP26A1CYP26B1CYP1B1HDAC3 | |
| SCHEMBL7720768 | 0.86 | NPC1 (0.56) | MAPTL3MBTL1NPC1CYP26A1CYP26B1 | |
| SCHEMBL7720766 | 0.86 | NPC1 (0.56) | MAPTL3MBTL1NPC1CYP26A1CYP26B1 | |
| SCHEMBL7721859 | 0.86 | TNFRSF1A (0.49) | MAPTCYP26A1CYP26B1CYP1B1HDAC3 | |
| SCHEMBL5694789 | 0.83 | CYP26A1 (0.59) | MAPTL3MBTL1SRD5A2CYP26A1CYP26B1 | |
| SCHEMBL5694786 | 0.83 | CYP26A1 (0.59) | MAPTL3MBTL1SRD5A2CYP26A1CYP26B1 | |
| SCHEMBL7069332 | 0.81 | MAPT (0.54) | MAPTL3MBTL1SRD5A2CYP26A1CYP26B1 | |
| SCHEMBL7069331 | 0.81 | MAPT (0.54) | MAPTL3MBTL1SRD5A2CYP26A1CYP26B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1142865-B1 | NOVEL 1,2-DIPHENYL-2-PROPEN-1-ONE DERIVATIVES | SANTEN PHARMACEUTICAL CO LTD (JP) | 2003-06-18 | — | — | EP | disclosed |
| US-6395932-B1 | AMINOALKYL-1,2-DIPHENYL-2-PROPEN-1-ONE WHICH LOWER INTRAOCULAR PRESSURE BY CAUSING MORPHOLOGICAL CHANGE IN TRABECULAR MESHWORK CELLS. | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2002-05-28 | — | — | US | disclosed |
| EP-1142865-A1 | NOVEL 1,2-DIPHENYL-2-PROPEN-1-ONE DERIVATIVES | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2001-10-10 | — | — | EP | disclosed |