Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | MAOB | P27338 | 8/20 | 0.47 |
| ▸ | MAOA | P21397 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.43 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.43 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.43 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7720768 | 1.00 | NPC1 (0.56) | NPC1RAB9AL3MBTL1MAPTMAOB | |
| SCHEMBL7720762 | 0.88 | RAB9A (0.54) | NPC1RAB9AL3MBTL1MAPTMAOB | |
| SCHEMBL7721859 | 0.86 | TNFRSF1A (0.49) | MAPTMAOBMAOALMNACYP1A2 | |
| SCHEMBL7721861 | 0.86 | TNFRSF1A (0.49) | MAPTMAOBMAOALMNACYP1A2 | |
| SCHEMBL7069204 | 0.86 | APP (0.51) | NPC1RAB9AL3MBTL1MAPTLMNA | |
| SCHEMBL7069202 | 0.86 | APP (0.51) | NPC1RAB9AL3MBTL1MAPTLMNA | |
| SCHEMBL3413340 | 0.84 | CYP1A2 (0.62) | NPC1RAB9AMAPTMAOBMAOA | |
| SCHEMBL5694689 | 0.83 | L3MBTL1 (0.61) | NPC1RAB9AL3MBTL1MAPTMAOB | |
| SCHEMBL5694692 | 0.83 | L3MBTL1 (0.61) | NPC1RAB9AL3MBTL1MAPTMAOB | |
| SCHEMBL3409990 | 0.82 | LMNA (0.50) | NPC1RAB9AMAPTMAOBMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6395932-B1 | AMINOALKYL-1,2-DIPHENYL-2-PROPEN-1-ONE WHICH LOWER INTRAOCULAR PRESSURE BY CAUSING MORPHOLOGICAL CHANGE IN TRABECULAR MESHWORK CELLS. | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2002-05-28 | — | — | US | disclosed |