Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.42 |
| ▸ | BAZ2B | Q9UIF8 | 6/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CGAS | Q8N884 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6483420 | 0.80 | BAZ2B (0.45) | LMNASMN1; SMN2PABPC1ATMBAZ2B | |
| SCHEMBL8056951 | 0.75 | TRPV1 (0.64) | TRPV1KMT2A | |
| SCHEMBL6483852 | 0.71 | TRPV1 (0.53) | BAZ2BTRPV1 | |
| SCHEMBL620196 | 0.71 | LMNA (0.74) | LMNASMN1; SMN2PABPC1ATMBAZ2B | |
| SCHEMBL2080129 | 0.71 | LMNA (0.50) | LMNASMN1; SMN2PABPC1ATMPOLB | |
| SCHEMBL620113 | 0.70 | BAZ2B (0.58) | LMNASMN1; SMN2PABPC1ATMBAZ2B | |
| SCHEMBL12868340 | 0.69 | LMNA (0.79) | LMNASMN1; SMN2PABPC1ATMBAZ2B | |
| SCHEMBL5316982 | 0.69 | LMNA (0.65) | LMNASMN1; SMN2PABPC1ATMBAZ2B | |
| SCHEMBL1444915 | 0.68 | SMN1; SMN2 (0.61) | LMNASMN1; SMN2ATMSMYD3POLB | |
| SCHEMBL5814925 | 0.68 | LMNA (0.61) | LMNASMN1; SMN2ATMSMYD3POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1319004-A2 | SUBSTITUTED AZEPINO[4,5-B]INDOLE DERIVATIVES | PHARMACIA & UPJOHN COMPANY (US) | 2003-06-18 | — | — | EP | disclosed |
| WO-2002024701-A2 | SUBSTITUTED AZEPINO[4,5B)INDOLE DERIVATIVES | PHARMACIA & UPJOHN COMPANY (US) | 2002-03-28 | — | — | WO | disclosed |