SCHEMBL7070089

SCHEMBL7070089

CCOc1ccc(CNc2cc(OC(CC)CCC(=O)O)ccc2NC(C)=O)c(Cl)c1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 1/20 0.36
FFAR4 Q5NUL3 1/20 0.36
MAPT P10636 4/20 0.35
EPHX1 P07099 1/20 0.35
LMNA P02545 3/20 0.35
TDP1 Q9NUW8 2/20 0.35
KMT2A Q03164 2/20 0.35
MEN1 O00255 1/20 0.35
CYP1A2 P05177 1/20 0.35
NR1H4 Q96RI1 2/20 0.35
EPHX2 P34913 1/20 0.35
ALDH1A1 P00352 5/20 0.34
RORC P51449 1/20 0.34
SMN1; SMN2 Q16637 3/20 0.33
TAS1R3 Q7RTX0 1/20 0.33
TAS1R1 Q7RTX1 1/20 0.33
KDM4E B2RXH2 1/20 0.33
TP53 P04637 1/20 0.33
HTT P42858 1/20 0.33
PPARD Q03181 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7064566 0.91 HDAC1 (0.39) MAPTLMNATDP1KMT2AMEN1
SCHEMBL7070085 0.83 MAPT (0.36) FFAR1FFAR4MAPTEPHX1LMNA
SCHEMBL7065219 0.80 IDO1 (0.38) MAPTTDP1KMT2AMEN1ALDH1A1
SCHEMBL6497406 0.79 BRD4 (0.41) FFAR1FFAR4MAPTEPHX1LMNA
SCHEMBL7068553 0.78 MEN1 (0.45) FFAR1MAPTLMNAKMT2AMEN1
SCHEMBL7132250 0.78 KDM4E (0.35) ALDH1A1SMN1; SMN2KDM4E
SCHEMBL7068049 0.77 CD38 (0.40) FFAR1LMNATDP1EPHX2ALDH1A1
SCHEMBL6301182 0.77 KMT2A (0.47) MAPTLMNAKMT2AMEN1CYP1A2
SCHEMBL7129639 0.76 HDAC1 (0.38) MAPTLMNAKMT2AMEN1ALDH1A1
SCHEMBL7064560 0.75 HRH3 (0.39) LMNATAS1R3TAS1R1KDM4EPPARD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004108686-A2 BENZIMIDAZOLE COMPOUNDS HAVING HYPOGLYCEMIC ACTIVITY FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2004-12-16 WO disclosed