Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7074222 | 0.88 | LMNA (0.62) | LMNAHTTGAASMN1; SMN2KMT2A | |
| SCHEMBL7074109 | 0.86 | ALDH1A1 (0.48) | CYP3A4LMNASMN1; SMN2ALDH1A1POLB | |
| SCHEMBL7071746 | 0.86 | MEN1 (0.54) | LMNAHTTGAASMN1; SMN2KMT2A | |
| SCHEMBL7071582 | 0.86 | LMNA (0.60) | LMNAHTTGAASMN1; SMN2KMT2A | |
| SCHEMBL7075122 | 0.86 | LMNA (0.65) | LMNAHTTSMN1; SMN2ALDH1A1USP2 | |
| SCHEMBL7132172 | 0.84 | ALDH1A1 (0.54) | LMNAHTTGAASMN1; SMN2KMT2A | |
| SCHEMBL7074809 | 0.84 | LMNA (0.53) | LMNAHTTGAASMN1; SMN2KMT2A | |
| SCHEMBL7071901 | 0.84 | LMNA (0.50) | LMNAHTTGAASMN1; SMN2KMT2A | |
| SCHEMBL7069983 | 0.84 | LMNA (0.58) | LMNAHTTSMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL7073993 | 0.83 | ALDH1A1 (0.60) | LMNAHTTSMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1025086-B1 | BENZAMIDINE DERIVATIVES AS FACTOR XA INHIBITORS | MERCK PATENT GMBH (DE) | 2003-06-25 | — | — | EP | disclosed |
| US-6492368-B1 | Benzamidine derivatives as factor XA inhibitors | MERCK PATENT GMBH (DE) | 2002-12-10 | — | — | US | disclosed |