SCHEMBL7071023

SCHEMBL7071023

FC(F)(F)c1ccc(OCCCOc2c(Br)cc(OCC=C(Cl)Cl)cc2Br)nc1

nearest known ligand 0.41

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.41
THRB P10828 1/20 0.40
MAPK1 P28482 1/20 0.37
MRGPRX4 Q96LA9 1/20 0.36
TSHR P16473 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
KMT2A Q03164 1/20 0.34
LMNA P02545 1/20 0.34
MAPT P10636 2/20 0.33
HPGD P15428 1/20 0.33
SCN9A Q15858 4/20 0.33
RAB9A P51151 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32
SCN10A Q9Y5Y9 2/20 0.32
LIPE Q05469 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7071130 0.98 L3MBTL1 (0.41) L3MBTL1THRBMAPK1MRGPRX4TSHR
Pyridalyl SCHEMBL29354972 0.89 KMT2A (0.39) L3MBTL1THRBMAPK1MRGPRX4TSHR
Pyridalyl SCHEMBL83386 0.89 KMT2A (0.39) L3MBTL1THRBMAPK1MRGPRX4TSHR
SCHEMBL7076327 0.87 KMT2A (0.39) L3MBTL1THRBMAPK1MRGPRX4TSHR
SCHEMBL7076494 0.86 MAPK1 (0.39) THRBMAPK1MRGPRX4TSHRSMN1; SMN2
SCHEMBL7074999 0.86 KMT2A (0.39) L3MBTL1THRBMAPK1MRGPRX4TSHR
SCHEMBL7078841 0.86 KMT2A (0.39) L3MBTL1THRBMAPK1MRGPRX4TSHR
SCHEMBL4139449 0.86 L3MBTL1 (0.40) L3MBTL1THRBMAPK1MRGPRX4KMT2A
SCHEMBL4624909 0.85 KMT2A (0.36) L3MBTL1THRBMAPK1MRGPRX4TSHR
SCHEMBL7075429 0.85 KMT2A (0.36) L3MBTL1THRBMAPK1MRGPRX4TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0785923-B1 DIHALOPROPENE COMPOUNDS, INSECTICIDAL/ACARICIDAL AGENTS CONTAINING SAME, AND INTERMEDIATES FOR THEIR PRODUCTION SUMITOMO CHEMICAL CO (JP) 2000-04-05 EP claimed
EP-0785923-A1 DIHALOPROPENE COMPOUNDS, INSECTICIDAL/ACARICIDAL AGENTS CONTAINING SAME, AND INTERMEDIATES FOR THEIR PRODUCTION SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1997-07-30 EP claimed
WO-1996011909-A1 DIHALOPROPENE COMPOUNDS, INSECTICIDAL/ACARICIDAL AGENTS CONTAINING SAME, AND INTERMEDIATES FOR THEIR PRODUCTION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1996-04-25 WO claimed
US-6589914-B2 The dihalopropene compounds of the general formula (I) have excellent insecticidal/acaricidal activity, so that they are satisfactorily effective for the control of noxious insects, mites and ticks. SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2003-07-08 US disclosed
US-20030073847-A1 Dihalopropene compounds, insecticidal/acaricidal agents containing same, and intermediates for their production SUMITOMO CHEMICAL COMPANY, LIMITED 2003-04-17 US disclosed
US-6376428-B1 Dihalopropene compounds, insecticidal/acaricidal agents containing same, and intermediates for their production SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2002-04-23 US disclosed
US-6268313-B1 CONTROLLING INSECTS, MITES, TICKS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2001-07-31 US disclosed
EP-0785923-B1 DIHALOPROPENE COMPOUNDS, INSECTICIDAL/ACARICIDAL AGENTS CONTAINING SAME, AND INTERMEDIATES FOR THEIR PRODUCTION SUMITOMO CHEMICAL CO (JP) 2000-04-05 EP disclosed
EP-0785923-A1 DIHALOPROPENE COMPOUNDS, INSECTICIDAL/ACARICIDAL AGENTS CONTAINING SAME, AND INTERMEDIATES FOR THEIR PRODUCTION SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1997-07-30 EP disclosed
WO-1996011909-A1 DIHALOPROPENE COMPOUNDS, INSECTICIDAL/ACARICIDAL AGENTS CONTAINING SAME, AND INTERMEDIATES FOR THEIR PRODUCTION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1996-04-25 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030073847-A1 Dihalopropene compounds, insecticidal/acaricidal agents containing same, and intermediates for their production DDT, DDC, AADAC L3MBTL1 1034/4885THRB 764/4885MAPK1 2232/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.