Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 14/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.47 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6307042 | 0.82 | CCR2 (0.77) | CCR2LMNAMAPTALDH1A1CYP1A2 | |
| SCHEMBL6302552 | 0.76 | CCR2 (0.62) | CCR2LMNAMAPTALDH1A1CYP1A2 | |
| SCHEMBL7076059 | 0.76 | CCR2 (0.68) | CCR2LMNAMAPTALDH1A1CYP1A2 | |
| SCHEMBL7076535 | 0.76 | CCR2 (0.56) | CCR2MAPTCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL7077464 | 0.76 | CCR2 (0.53) | CCR2ABCB11 | |
| SCHEMBL11466032 | 0.75 | PTGDR2 (0.57) | CCR2LMNAMAPTALDH1A1CYP1A2 | |
| SCHEMBL15512442 | 0.75 | CMA1 (0.50) | MAPTALDH1A1HPGDHTT | |
| SCHEMBL9239991 | 0.75 | CCR2 (0.67) | CCR2LMNAMAPTGAAHTT | |
| SCHEMBL7077386 | 0.74 | CCR2 (0.56) | CCR2LMNAMAPTALDH1A1CYP1A2 | |
| SCHEMBL6599738 | 0.74 | CCR2 (1.00) | CCR2LMNAMAPTALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003504-B1 | INDOLE DERIVATIVES AND THEIR USE AS MCP-1 ANTAGONISTS | ASTRAZENECA AB (SE) | 2003-07-02 | — | — | EP | claimed |