Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 15/20 | 0.56 |
| ▸ | ABCB11 | O95342 | 4/20 | 0.51 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6307041 | 0.82 | CCR2 (0.72) | CCR2ABCB11TBXA2R | |
| SCHEMBL7077464 | 0.77 | CCR2 (0.53) | CCR2ABCB11TBXA2R | |
| SCHEMBL6300631 | 0.77 | CCR2 (0.52) | CCR2ABCB11TBXA2RKDM4ECYP1A2 | |
| SCHEMBL7072402 | 0.76 | CCR2 (0.59) | CCR2ABCB11CYP1A2CYP3A4MAPT | |
| SCHEMBL7076337 | 0.76 | CCR2 (0.69) | CCR2ABCB11TBXA2R | |
| SCHEMBL11466147 | 0.74 | CCR2 (0.55) | CCR2ABCB11TBXA2RKDM4ECYP1A2 | |
| SCHEMBL9239098 | 0.74 | ALDH1A1 (0.42) | KDM4EHPGDHSD17B10 | |
| SCHEMBL9238617 | 0.73 | MEN1 (0.41) | CCR2CYP1A2CYP3A4MAPTCYP2C9 | |
| SCHEMBL7080358 | 0.73 | CCR2 (0.70) | CCR2ABCB11CYP1A2CYP3A4MAPT | |
| SCHEMBL11459984 | 0.73 | CCR2 (0.50) | CCR2ABCB11TBXA2RKDM4ECYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003504-B1 | INDOLE DERIVATIVES AND THEIR USE AS MCP-1 ANTAGONISTS | ASTRAZENECA AB (SE) | 2003-07-02 | — | — | EP | claimed |