Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 3/20 | 0.59 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.50 |
| ▸ | HTR1A | P08908 | 5/20 | 0.47 |
| ▸ | HTR2A | P28223 | 5/20 | 0.47 |
| ▸ | HTR2C | P28335 | 5/20 | 0.47 |
| ▸ | HTR7 | P34969 | 5/20 | 0.47 |
| ▸ | DRD3 | P35462 | 5/20 | 0.47 |
| ▸ | DRD2 | P14416 | 4/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 4/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 2/20 | 0.43 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.42 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.42 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27236983 | 0.88 | METAP1 (0.46) | METAP1SIGMAR1HTR1AHTR2AHTR2C | |
| SCHEMBL9048859 | 0.86 | CYP19A1 (0.58) | METAP1CYP19A1ACHEDGAT1ITGB3 | |
| SCHEMBL6272440 | 0.83 | METAP1 (0.65) | METAP1SIGMAR1HTR1AHTR2AHTR2C | |
| SCHEMBL16142397 | 0.83 | METAP1 (0.64) | METAP1SIGMAR1HTR1AHTR2AHTR2C | |
| SCHEMBL9243642 | 0.82 | METAP1 (0.59) | METAP1CYP19A1SRD5A1SRD5A2DGAT1 | |
| SCHEMBL10756226 | 0.82 | CYP26A1 (0.45) | METAP1CYP19A1DGAT1ITGB3ITGA2B | |
| SCHEMBL6268218 | 0.82 | HTR2C (0.51) | METAP1SIGMAR1HTR1AHTR2AHTR2C | |
| SCHEMBL27236990 | 0.81 | HTR1A (0.41) | METAP1HTR1AHTR2AHTR2CHTR7 | |
| SCHEMBL28526984 | 0.80 | HTR2A (0.43) | METAP1HTR1AHTR2AHTR2CHTR7 | |
| SCHEMBL8601600 | 0.80 | METAP1 (0.65) | METAP1SIGMAR1HTR1AHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1105367-B1 | SUBSTITUTED CINNAMIC ACIDS AND CINNAMIC ACID ESTERS | BAYER AG (DE) | 2003-06-18 | — | — | EP | disclosed |
| US-6455725-B1 | Substituted cinnamic acids and cinnamic acid esters | BAYER AKTIENGESELLSCHAFT (DE) | 2002-09-24 | — | — | US | disclosed |
| EP-1105367-A1 | SUBSTITUTED CINNAMIC ACIDS AND CINNAMIC ACID ESTERS | Bayer Aktiengesellschaft (DE) | 2001-06-13 | — | — | EP | disclosed |
| WO-2000010963-A1 | SUBSTITUTED CINNAMIC ACIDS AND CINNAMIC ACID ESTERS | BAYER AKTIENGESELLSCHAFT (DE) | 2000-03-02 | — | — | WO | disclosed |
| US-4443626-A | ANTIINFLAMMATORY, ANTIALLERGENS, ANALGESICS, ANTICOAGULANTS, ANTIPRETICS, OR ANTICHOLESTEROL AGENTS | HISAMITSU PHARMACEUTICAL CO., INC. (JP) | 1984-04-17 | — | — | US | disclosed |