Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.58 |
| ▸ | CYP26A1 | O43174 | 7/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | GLA | P06280 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.50 |
| ▸ | GMNN | O75496 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7072860 | 0.86 | METAP1 (0.59) | CYP19A1CYP26A1METAP1DGAT1ITGB3 | |
| SCHEMBL4622497 | 0.85 | CYP26A1 (0.70) | CYP19A1CYP26A1DGAT1ITGB3ITGA2B | |
| SCHEMBL9243642 | 0.83 | METAP1 (0.59) | CYP19A1CYP26A1METAP1DGAT1ITGB3 | |
| SCHEMBL6268218 | 0.83 | HTR2C (0.51) | CYP19A1METAP1DGAT1ITGB3ITGA2B | |
| SCHEMBL10756226 | 0.83 | CYP26A1 (0.45) | CYP19A1CYP26A1GAALMNAMAPT | |
| SCHEMBL9854906 | 0.82 | CYP19A1 (0.53) | CYP19A1CYP26A1MEN1GLAKMT2A | |
| SCHEMBL6272399 | 0.80 | METAP1 (0.65) | CYP19A1CYP26A1METAP1ACHECYP24A1 | |
| SCHEMBL27236990 | 0.79 | HTR1A (0.41) | CYP19A1MEN1KMT2AGAAKDM4E | |
| SCHEMBL6695612 | 0.79 | METAP1 (0.57) | CYP19A1METAP1ACHE | |
| SCHEMBL10750981 | 0.77 | ITGB3 (0.51) | MEN1KMT2ANPC1ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0743064-A1 | Leukotriene antagonists for use in the treatment or prevention of alzheimer's disease | ELI LILLY AND COMPANY (US) | 1996-11-20 | — | — | EP | disclosed |
| US-5462954-A | Antiinflammatory, antiallergens; treating asthma | ELI LILLY AND COMPANY (US) | 1995-10-31 | — | — | US | disclosed |
| EP-0544488-A2 | Substituted phenyl phenol leukotriene antagonists | ELI LILLY AND COMPANY (US) | 1993-06-02 | — | — | EP | disclosed |