Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.42 |
| ▸ | FAAH | O00519 | 2/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.41 |
| ▸ | GPX4 | P36969 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | F12 | P00748 | 1/20 | 0.38 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6475467 | 0.92 | HDAC1 (0.51) | HDAC1HDAC6HTR6LMNACHRM2 | |
| SCHEMBL6786012 | 0.84 | HDAC1 (0.47) | HDAC1HDAC6TRPV1FAAHLMNA | |
| SCHEMBL7466922 | 0.83 | HDAC1 (0.46) | HDAC1HDAC6TRPV1FAAHLMNA | |
| SCHEMBL6474214 | 0.80 | LMNA (0.60) | TRPV1FAAHLMNAMAPTBAZ2B | |
| SCHEMBL6474858 | 0.79 | HDAC1 (0.51) | HDAC1HDAC6HTR6CHRM2CHRM4 | |
| SCHEMBL6480968 | 0.79 | KDM4E (0.49) | HTR6PTGDR2KMT2AENPP2 | |
| SCHEMBL6474153 | 0.78 | KDM4E (0.61) | HDAC1HDAC6BAZ2BCHRM2CHRM4 | |
| SCHEMBL6475292 | 0.78 | HDAC1 (0.56) | HDAC1HDAC6CHRM2CHRM4CHRM1 | |
| SCHEMBL7069900 | 0.77 | KDM4E (0.60) | HDAC1HDAC6BAZ2BCHRM2CHRM4 | |
| SCHEMBL6475536 | 0.77 | HDAC1 (0.55) | HDAC1HDAC6CHRM2CHRM4CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1319004-A2 | SUBSTITUTED AZEPINO[4,5-B]INDOLE DERIVATIVES | PHARMACIA & UPJOHN COMPANY (US) | 2003-06-18 | — | — | EP | disclosed |
| WO-2002024701-A2 | SUBSTITUTED AZEPINO[4,5B)INDOLE DERIVATIVES | PHARMACIA & UPJOHN COMPANY (US) | 2002-03-28 | — | — | WO | disclosed |