Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 2/20 | 0.48 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | NCF1 | P14598 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5748240 | 0.92 | CRHBP (0.50) | CRHBPCRHR2MAPTGFERSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL5749583 | 0.76 | NUDT1 (0.69) | CRHBPCRHR2MAPTGFERSMN1; SMN2 | |
| SCHEMBL2727649 | 0.76 | PDPK1 (0.46) | NUDT1PDPK1MKNK1MKNK2ROCK1 | |
| SCHEMBL5747568 | 0.76 | NUDT1 (0.65) | CRHBPCRHR2MAPTGFERSMN1; SMN2 | |
| SCHEMBL7077159 | 0.74 | ROCK1 (0.61) | CRHBPCRHR2MAPTGFERSMN1; SMN2 | |
| SCHEMBL7076191 | 0.68 | NUDT1 (0.55) | CRHBPCRHR2MAPTGFERSMN1; SMN2 | |
| SCHEMBL21516212 | 0.67 | CRHBP (0.88) | CRHBPCRHR2MAPTGFERSMN1; SMN2 | |
| SCHEMBL31472334 | 0.67 | CRHBP (0.88) | CRHBPCRHR2MAPTGFERSMN1; SMN2 | |
| SCHEMBL21516206 | 0.67 | CRHBP (0.55) | CRHBPCRHR2MAPTGFERSMN1; SMN2 | |
| SCHEMBL21516848 | 0.67 | CRHBP (0.55) | CRHBPCRHR2MAPTGFERSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1321169-A1 | Combination of a serotonin receptor antagonist with a histidine decarboxylase inhibitor as a medicament | Biofrontera Pharmaceuticals AG (DE) | 2003-06-25 | — | — | EP | disclosed |
| US-5863924-A | Aryl pyrimidine derivatives | SYNTEX (U.S.A.) INC. (US) | 1999-01-26 | — | — | US | disclosed |