Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | LSS | P48449 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.49 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | F2 | P00734 | 1/20 | 0.48 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7986862 | 0.84 | F10 (0.57) | TSHRALDH1A1SMN1; SMN2GAAF2 | |
| SCHEMBL7074115 | 0.84 | KDM4E (0.59) | TSHRLMNAALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL7070279 | 0.84 | TDP1 (0.51) | TSHRLSSLMNAL3MBTL1ALDH1A1 | |
| SCHEMBL7074514 | 0.83 | TP53 (0.53) | LSSLMNAALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL7075843 | 0.83 | ALDH1A1 (0.71) | TSHRLMNAL3MBTL1ALDH1A1KDM4E | |
| Acetic Acid SCHEMBL28743952 | 0.82 | SMN1; SMN2 (0.49) | TSHRLSSLMNAL3MBTL1ALDH1A1 | |
| Acetic Acid SCHEMBL27550435 | 0.82 | ALDH1A1 (0.57) | LMNAALDH1A1KDM4ESMN1; SMN2GAA | |
| SCHEMBL30576797 | 0.82 | GAA (0.60) | TSHRLMNAL3MBTL1ALDH1A1KDM4E | |
| Acetic Acid SCHEMBL27530353 | 0.81 | MEN1 (0.53) | LSSLMNAALDH1A1KDM4ESMN1; SMN2 | |
| Acetic Acid SCHEMBL27525165 | 0.81 | LMNA (0.67) | TSHRLMNAL3MBTL1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1025086-B1 | BENZAMIDINE DERIVATIVES AS FACTOR XA INHIBITORS | MERCK PATENT GMBH (DE) | 2003-06-25 | — | — | EP | disclosed |
| US-6492368-B1 | Benzamidine derivatives as factor XA inhibitors | MERCK PATENT GMBH (DE) | 2002-12-10 | — | — | US | disclosed |
| EP-1025086-A1 | BENZAMIDINE DERIVATIVES AS FACTOR XA INHIBITORS | MERCK PATENT GmbH (DE) | 2000-08-09 | — | — | EP | disclosed |
| WO-1999016751-A1 | BENZAMIDINE DERIVATIVES AS FACTOR XA INHIBITORS | MERCK PATENT GMBH (DE) | 1999-04-08 | — | — | WO | disclosed |