Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 6/20 | 0.44 |
| ▸ | TACR1 | P25103 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.41 |
| ▸ | YAP1 | P46937 | 3/20 | 0.41 |
| ▸ | BACE1 | P56817 | 2/20 | 0.41 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6042351 | 0.89 | REN (0.46) | RENTACR1YAP1BACE1BACE2 | |
| SCHEMBL6043110 | 0.89 | REN (0.46) | RENTACR1YAP1BACE1BACE2 | |
| SCHEMBL6042241 | 0.89 | REN (0.49) | RENTACR1YAP1PRMT5JAK2 | |
| SCHEMBL6041545 | 0.89 | REN (0.47) | RENTACR1GPR119YAP1PRMT5 | |
| SCHEMBL7080920 | 0.87 | REN (0.55) | RENTACR1YAP1PRMT5 | |
| SCHEMBL6041532 | 0.87 | REN (0.47) | RENTACR1YAP1PRMT5 | |
| SCHEMBL4872229 | 0.86 | REN (0.41) | RENTACR1GPR119YAP1BACE1 | |
| SCHEMBL6041517 | 0.86 | TACR1 (0.42) | RENTACR1GPR119YAP1BACE1 | |
| SCHEMBL2807737 | 0.86 | BACE1 (0.45) | RENTACR1YAP1BACE1BACE2 | |
| SCHEMBL2807746 | 0.86 | REN (0.44) | RENTACR1YAP1BACE1BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863875-B1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | HOFFMANN LA ROCHE (CH) | 2003-06-04 | — | — | EP | disclosed |